Dynamically monitoring tissue factor and tissue factor pathway inhibitor following secondary brain injury  

作　　者：吴雪海 施小燕 干建新 卢兴国 江观玉 周君富 

机构地区：[1]Department of Emergency

出　　处：《Chinese Journal of Traumatology》2003年第2期114-117,共4页中华创伤杂志（英文版）

摘　　要：Objective: To study the altering rule of coagulation function at molecular level in patients with secondary brain injury (SBI). Methods: Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were studied in 32 patients 1, 2, 3 and 7 days after craniocerebral injury. Repeated cranial CT scans and platelet counts were made simultaneously. Same measurements were done in 30 normal adults except CT scan. Results: No obvious difference was found in age, sex and platelet count between the injured and the normal groups. TFPI/TF decreased markedly in the first week after injury in patients with SBI, but only decreased on the 7th day in the patients without obvious SBI. For the patients who developed delayed intracranial hematoma (DIH) or hematoma enlargement, TF rose only 1 and 2 days after injury, but TFPI had a tendency to rise again after a fall on the 3rd day. For those patients who developed no DIH, TF rose all the time within the 1st week. Conclusions: Decrease of TFPI/TF for a long time, especially within 3 days after injury, may be one of the most important reasons for SBI. High expression of TF for a relative short time and increase of TFPI after a fall within 3 days may be one of the important reasons for DIH or hematoma enlargement.

关 键 词：Blood coagulation factors THROMBOPLASTIN Brain injuries  Department of Emergency  Second Affiliated Hospital  Medical School of Zhejiang University  Hangzhou 310009  China (Wu XH  Shi XY  Gan JX  Lu XG  Jiang GY and Zhou JF) 

分 类 号：R651[医药卫生—外科学]