补经合剂对初老大鼠下丘脑内单胺类神经递质的影响  

Effect of Bujing Heji on monoamine in old rats brain

作　　者：徐晓娟[1] 金沈锐[2] 秦旭华[3] 杨家林[4] 

机构地区：[1]成都中医药大学妇科教研室,成都610075 [2]成都中医药大学生物化学与分子生物学教研室,成都610075 [3]成都中医药大学中药教研室,成都610075 [4]成都中医药大学,成都610075

出　　处：《四川生理科学杂志》2003年第2期67-69,共3页Sichuan Journal of Physiological Sciences

基　　金：四川省教委青年基金课题

摘　　要：目的 :从大鼠脑内单胺类神经递质途径 ,探讨补经合剂对初老大鼠下丘脑 垂体 卵巢轴功能的影响。方法 :雌性初老大鼠为自然肾虚模型 ,采用荧光分光光度法观察该方对下丘脑内单胺类神经递质多巴胺(DA)、去甲肾上腺素 (NE)、5 羟色胺 (5 HT)含量的影响。结果 :补经合剂低剂量组 (7 8g·kg 1)、高剂量组 (3 1 g·kg 1)均可明显降低初老大鼠下丘脑内NE的影响 (P <0 .0 5 ) ;同时低剂量组还可明显降低初老大鼠脑内DA的含量 (P <0 .0 5 )。结论 :补经合剂可明显降低初老大鼠下丘脑内NE、DA含量 ,提示该方可能通过影响下丘脑内单胺类神经递质的水平而对下丘脑 垂体 卵巢轴进行调节 ,从而发挥治疗作用。Objective: To study the effect on monoamine in old rats brain of Bujing Heji. Methods: Old female rats were employed to study the change of monoamine in brain. Dopamine (DA), Norepine phrine (NE), 5 hydroxytryptamine (5 HT) were studied respectively. Results: Decrease of NE was observed after Bujing Heji 7.8g·kg 1 and 31g·kg 1 were administrated, which was 0.010±0.008μg·g 1 and 0.007±0.003μg·g 1 brain. Decrease of DA was also observed by 7.8g·kg 1 Bujing Heji (0.096±0.027μg·g 1 brain) compred with young rats and nin drug old rats, NE and DA is remarked lower (P<0.05). Conclusion: Decrease of NE, DA can be induced by Bujing Heji in old Female rats.

关 键 词：补经合剂 初老大鼠 下丘脑 单胺类神经递质 多巴胺 去甲肾上腺素 5-羟色胺 

分 类 号：R285.5[医药卫生—中药学]