Characterization of two Achromobacter xylosoxidans isolates from patients with pertussis-like symptoms  

作　　者：Fiorella Orellana-Peralta Michelle Jacinto Maria J.Pons Cláudia Gomes Carlos Bada Isabel Reyes Juana del Valle Mendoza Joaquim Ruiz 

机构地区：[1]Facultad de Ciencias de la Salud.Universidad Peruana de Ciencias Aplicadas-LiPC,Lima,Peru [2]ISGlobal,Barcelona Ctr.Int.Health Res.(CRESIB),Hospital Clinic-Universitat de Barcelona [3]Hospital de Emergencias Pediatricas.Lima,Peru [4]Instituto de Investigacion Nutrirional,Lima,Peru

出　　处：《Asian Pacific Journal of Tropical Medicine》2015年第6期465-468,共4页亚太热带医药杂志（英文版）

基　　金：supported by Sanoti Aventis del Peru;a fellowship from the program 13.of the ISCIII(grant number:CES11/012);a PhD fellowship of the ISCIII(FI12/00561);a fellowship from CONCYTEC/FONDECYT

摘　　要：Objective:To characterize two Achromobaeter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program.Methods:Nasopharyngeal swabs from 2 children under 1 year of age with clinical suspicion of pertussis were analyzed by culture and PCR.Results:Two Achromobaeter xylosoxidans A8,closely related to Bordetella spp.were recovered from 2 patients diagnosed of pertussis,both carrying the ptxA gene and IS418 the pertussis toxin encoding gene.Subsequently,antibiotic susceptibility was evaluated by disk-diffusion method and by PCR.Conclusions:Although more detailed studies are needed,the present data highlight the possibility that Achromobaeter xylosoxidans.closely related Bordetella pertussis microorganisms and not covered under the vaccine umbrella,might also result in cases of whooping cough.Thereby further surveillance is necessary to determine the extension and relevance of their pathogenic role in order to discriminate their real public health implication.Objective:To characterize two Achromobaeter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program.Methods:Nasopharyngeal swabs from 2 children under 1 year of age with clinical suspicion of pertussis were analyzed by culture and PCR.Results:Two Achromobaeter xylosoxidans A8,closely related to Bordetella spp.were recovered from 2 patients diagnosed of pertussis,both carrying the ptxA gene and IS418 the pertussis toxin encoding gene.Subsequently,antibiotic susceptibility was evaluated by disk-diffusion method and by PCR.Conclusions:Although more detailed studies are needed,the present data highlight the possibility that Achromobaeter xylosoxidans.closely related Bordetella pertussis microorganisms and not covered under the vaccine umbrella,might also result in cases of whooping cough.Thereby further surveillance is necessary to determine the extension and relevance of their pathogenic role in order to discriminate their real public health implication.

关 键 词：ACHROMOBACTER xylosoxidans BORDETELLA PERTUSSIS 

分 类 号：R725.1[医药卫生—儿科]