Echovirus serotypes circulating in Malaysia from 2002 to 2013  

作　　者：Jeyanthi Suppiah TS Saraswathy Subramaniam Amry Khursany Ismail Apandi Yusof Zainah Sa'at 

机构地区：[1]Virology Unit,Infectious Disease Research Centre,Institute for Medical Research

出　　处：《Asian Pacific Journal of Tropical Medicine》2016年第3期246-249,共4页亚太热带医药杂志（英文版）

基　　金：supported by Institute for Medical Research Operational Grant(Vol:040300/OS27403)

摘　　要：Objective:To identify the circulating serotypes of human echovinis in Malaysia from 2002 in 2013.Methods:A toial of 31 retrospective samples from non-polio acute flacid paralysis,hand-food-and-mouth disease,viral meningitis and enterovirus cases were subjected to amplification of partial VPI gene by RT-PCR.Results:Sequencing and phylogeneiic analysis of the partial sequences identified presence of human echovinis and human coxsackie viruses.It was found that echovinis 11 was the commonly circulating serotype followed by echovinis6.echovinis 7.echovinis 3.echovinis 9.echovinis 30 and echovinis I in decreasing order.Additionally two types of human coxsackie virus isolates were detected which were coxsackie A24 and B3.Condusions:From the findings,there is a possibility that echovinis 11 is the predominant serotype among Malaysian patients with echovinis infection.However,a larger sample size will yield a more confident result to support this evidence.____________________Objective: To identify the circulating serotypes of human echovirus in Malaysia from 2002 to 2013. Methods: A total of 31 retrospective samples from non-polio acute flacid paralysis, hand-food-and-mouth disease, viral meningitis and enterovirus cases were subjected to amplification of partial VPl gene by RT-PCR. Results: Sequencing and phylogenetic analysis of the partial sequences identified presence of human echovirus and human coxsackie viruses. It was found that echovirus 11 was the commonly circulating serotype followed by echovirus 6, echovirus 7, echovirus 3. echovirus 9. echovirus 30 and echovirus I in decreasing order. Additionally two types of human coxsackie virus isolates were detected which were coxsackie A24 and B3. Conclusions: From the findings, there is a possibility that echovirus 11 is the predominant serotypc among Malaysian patients with echovirus infection. However, a larger sample size will yield a more confident result to support this evidence.

关 键 词：ECHOVIRUS VPI MALAYSIA PHYLOGENETIC SEROTYPE 

分 类 号：R512.5[医药卫生—内科学]