参葛定渴片对2型糖尿病大鼠糖代谢调节作用的实验研究  

Regulating effect of Shenge Tablets on glycometabolism of type 2 diabetic rats

作　　者：苏宏硕 于丹[1] 陈楠[1] 柳辰跃 都晓伟[1] 

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《药物评价研究》2015年第5期508-511,共4页Drug Evaluation Research

基　　金：黑龙江省教育厅科学技术研究项目(编号11531338)

摘　　要：目的考察参葛定渴片对2型糖尿病大鼠糖代谢的调节作用。方法采用ig高脂高糖脂肪乳加ip小剂量链脲佐菌素(STZ)的方法,建立2型糖尿病大鼠模型。将造模成功的大鼠随机分为模型组、阳性组和参葛定渴片高、中、低剂量组。实验各组均连续给药4周。同时取健康大鼠为对照组,观察各组大鼠行为学指标,检测其血糖、糖耐量、血清胰岛素水平。结果与对照组比较,模型组体质量下降,血糖值显著升高、糖耐量能力降低以及血清胰岛素水平升高。与模型组比较,阳性组和参葛定渴片高、中剂量组可显著降低糖尿病大鼠的血糖和血清胰岛素水平(P<0.001、0.01),且参葛定渴片高剂量组可改善糖尿病大鼠的糖耐量(P<0.01)。结论参葛定渴片对2型糖尿病大鼠的糖代谢具有调节作用,可改善糖尿病大鼠的胰岛素抵抗状态。Objective To study the effect of Shenge Tablets on glycometabolism of type 2 diabetic rats. Methods Type 2 diabetic rats were established by feeding high glucose and lipoids food and injecting small dose of streptozotocin. Then the models were randomized into model group, positive control group, and low-, mid-, high-dose Shenge Tablets groups. The rats in each group was administered by ig gavage for 30 d, then, their behavior, blood glucose, sugar tolerance, and serum insulin were detected. Results Compared with the normal control group, the body weight and the levels of blood glucose, sugar tolerance, and serum insulin of model group showed significant differences(P < 0.001). Compared with the model group, the levels of blood glucose, serum insulin of positive control group, mid-and high-dose Shenge Tablets groups were significantly decreased(P < 0.001, 0.01); The level of sugar tolerance of large dose group was significantly decreased(P < 0.01). Conclusion Shenge Tablets can effectively regulate the glycometabolism of type 2 diabetic rats and improve their insulin resistance.

关 键 词：2型糖尿病 参葛定渴片 链脲佐菌素 糖代谢 

分 类 号：R285.5[医药卫生—中药学]