干扰素α-1b灌肠治疗小儿腹泻的疗效观察  

The Clinical Effect of Interferon α-1b Enema Treatment in Pediatric Patients with Diarrhea

作　　者：黄路圣[1] 叶林华[1] 黄云[1] 

机构地区：[1]江苏省泰兴市人民医院儿科,江苏泰兴225400

出　　处：《药物生物技术》2015年第6期519-521,共3页Pharmaceutical Biotechnology

摘　　要：观察干扰素α-1b灌肠治疗小儿腹泻的临床效果。选择该院2011年1月至2013年1月110例小儿腹泻患者,随机分为实验组和对照组,对照组55例患儿采用常规治疗的方法,实验组55例患儿给予干扰素α-1b灌肠治疗,分析比较两组患儿的治疗效果。实验组患儿和对照组患儿在治疗2 d后,实验组患儿的腹泻次数明显少于对照组患儿(P<0.05),具有统计学意义;实验组患儿临床症状消失、大便常规恢复正常的治疗时间明显少于对照组患儿(P<0.05),具有统计学意义;实验组患儿临床治疗总有效率96.36%,高于对照组患儿的治疗总有效率74.55%(P<0.05),具有统计学意义。在常规治疗的基础上加用干扰素α-1b灌肠治疗可以有效改善小儿腹泻患儿的临床症状,缩短治疗时间,具有较好的安全性和稳定性,副作用小,值得临床推广使用。To observe the clinical effect of interferon α-1b enema treatment in pediatric patients with diarrhea. A total of 110 cases of pediatric patients with diarrhea were included from Jan 2011 to Jan 2013,who were divided into experimental group and control group randomly. There were 55 cases in the control group which were treated with routine methods and,55 cases in the experimental group were treated with interferon α-1b enema,respectively. The results showed that the frequency of diarrhea in the patients of experimental group was significantly lower than the patients in the control group( P < 0. 05). The duration of clinical symptoms and time of stool returned to normal in the patients of experimental group were significantly less than patients in the control group( P <0. 05). The total effective rates of experimental group and control group were 96. 36% and 74. 55%,respectively. The Interferonα-1b enema treatment can improve the clinical symptoms in pediatric patients with diarrheae and shorten the treatment time. It had few side effects and safe,was effective to pediatric patients and worthy to be applied in clinic.

关 键 词：干扰素α-1 灌肠治疗 小儿腹泻 疗效观察 

分 类 号：R725.7[医药卫生—儿科]