主动和被动吸烟者尿尼古丁代谢产物排泄时间和总量的比较研究  

The Comparision of Excretive Time and Total Quantity of Urinary Nicotine Metabolites between Active and Passive Smokers

作　　者：魏一欣[1] 周世伟[1] 

机构地区：[1]中国预防医学科学院环境卫生与卫生工程研究所

出　　处：《卫生研究》1992年第1期24-26,共3页Journal of Hygiene Research

摘　　要：本研究选择主动吸烟者4人,被动吸烟者6人,通过人体暴露试验,采用DETB萃取法测定其尿中的尼古丁代谢产物。结果表明,对于一次性剂量暴露试验,应以总排泄量作为比较依据;主动吸烟者尿尼古丁代谢产物的排泄完全时间小于36小时,被动吸烟者约为24小时;主、被动吸烟者的代谢半衰期均约为12小时;在本研究条件下,主、被动吸烟者排泄总量比为5:1。Four active smokers and six passive smokers were selected for the test; the six subjects were exposed in the smoke-polluted environment created by the four active smokers who smoked twenty-four cigarettes during two hours. Their urinary nicotine metabolites were detected by using the method of diethylthiobarbituric acid(DETB)-extraction. The results showed that, for the exposed test of only one dose, accumulative quantity of urinary nicotine metabolites should be regarded as comparative basis; the complete excretion time of urinary nicotine metabolites was less than 36 hours for the active smokers, and was about 24 hours for the passive smokers;the half life time was about 12 hours for both the active and passive smokers; in this condition, the ratio of total excretive quantity between active and passive smokers was 5 to 1.

关 键 词：主动吸烟 被动吸烟 尼古丁 代谢物 

分 类 号：R163[医药卫生—公共卫生与预防医学]