磁共振灌注加权成像评价宫颈癌同步放化疗疗效的初步研究  

Primary study on perfusion-weighted imaging in concurrent chemoradiotherapy of cervical cancer

作　　者：王晓煜[1] 王越[1] 于韬[1] 罗娅红[1] 

机构地区：[1]辽宁省肿瘤医院医学影像科,辽宁沈阳110042

出　　处：《肿瘤影像学》2016年第1期75-80,共6页Oncoradiology

基　　金：国家公益性行业科研专项(No:201402020);国家科技支撑计划子课题(No:2014BAI17B01)

摘　　要：目的:研究磁共振灌注加权成像(perfusion-weighted imaging,PWI)在宫颈癌同步放化疗前后灌注参数的差异,探索宫颈癌同步放化疗疗效差异与PWI灌注参数之间的关系。方法:回顾性分析经病理确诊的宫颈癌患者20例,接受同步放化疗前后进行PWI扫描,以肿块强化最明显处作为感兴趣区,生成时间-强度曲线(time-intensity curve,TIC),并测量强化峰值(peak height,PH)、最大上升斜率(maximum slope of increase,MSI)及达峰时间(time to peak,TTP)。分析治疗前后各项灌注参数的变化。结果:同步放化疗后,PH、MSI较治疗前降低(399.05±45.39 vs.278.32±35.09、38.57±2.77 vs.19.55±2.49,P=0.000、0.000),TTP较治疗前延长(40.49±4.18 vs.66.15±5.11,P=0.000)。治疗有效组PH、MSI高于治疗无效组(411.79±43.40 vs.360.80±27.44、39.53±2.27 vs.35.69±2.16,P=0.025、0.004)。结论:PWI在宫颈癌同步放化疗的疗效评价和治疗前预测同步放化疗疗效中均有价值,为临床提供除形态学之外的功能性评价。Objective: To study the differences and relationship of perfusion-weighted imaging(PWI) between pre- and post-concurrent chemoradiotherapy of cervical cancer. Methods: Twenty patients with cervical cancer confirmed by pathology were retrospectively analyzed. All the patients underwent PWI before and after concurrent chemoradiotherapy. The most enhanced region of tumor was selected as region of interest(ROI). The time-intensity curve(TIC) was made, then peak height(PH), maximum slope of increase(MSI), and time to peak(TTP) were analyzed. Results: After concurrent chemoradiotherapy, PH and MSI were decreased(399.05±45.39 vs. 278.32±35.09, 38.57±2.77 vs. 19.55±2.49; P=0.000 and 0.000), and TTP was prolonged(40.49±4.18 vs. 66.15±5.11, P=0.000). PH and MSI in the effective treatment group were higher than those in the ineffective treatment group(411.79±43.40 vs. 360.80±27.44, 39.53±2.27 vs. 35.69±2.16; P=0.025 and 0.004). Conclusion: PWI is valuable in the evaluation and prediction of the efficacy of concurrent chemoradiotherapy of cervical cancer. It can provide functional evaluation besides morphology.

关 键 词：宫颈癌 磁共振灌注加权成像 疗效评价 同步放化疗 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.33[医药卫生—诊断学]