老年H型高血压颈动脉狭窄程度与血脂和炎性因子的相关性研究  

Correlation between Degree of Carotid Stenosis and Lipids,Inflammatory Factors in Elderly H-hypertensive Patients

作　　者：刘瑶[1] 李俊峰[1] 高金全[1] 张亚西[1] 王安伟[1] 

机构地区：[1]四川省崇州市人民医院,611230

出　　处：《医学研究杂志》2015年第4期146-149,共4页Journal of Medical Research

摘　　要：目的探讨老年H型高血压颈动脉狭窄程度与血脂和炎性因子的相关性。方法将198例老年原发性高血压患者按照血浆同型半胱氨酸(homocysteine,Hcy)的水平高低分为H型高血压组(Hcy≥10μmol/L,n=104例)和单纯型高血压组(Hcy<10μmol/L,n=94),并以100例健康体检者为对照组,分析颈动脉狭窄程度与血脂和炎性因子的相关性。结果与健康对照组相比,H型高血压和单纯高血压组的IMT、斑块指数、僵硬度、hs-CRP、IL-1、IL-6和TNF-α均显著升高,扩张性明显降低,且H型高血压组的上述指标改变程度亦明显高于单纯高血压组(P<0.05);相关分析显示,颈动脉狭窄程度与炎性因子和血脂指标均呈正相关(P<0.05);多元回归分析显示,Hcy、低密度脂蛋白胆固醇和hs-CRP是高危因子。结论 H型高血压患者更容易发生颈动脉狭窄,且与血脂和炎性因子水平密切相关。Objective To explore the correlation between degree of carotid stenosis and lipids,inflammatory factors in elderly hypertensive patients with high homocysteine.Methods The 198 cases of elderly patients with hypertension were divided into high and low levels of H-hypertensive group [homocysteine( Hcy) ≥10μmol / L,104 cases] and simple hypertension group( Hcy < 10μmol / L,94cases) according to plasma Hcy,and 100 healthy subjects were selected as the control group.The correlation between carotid stenosis and lipid,inflammatory factors were analyzed.Results Compared with the healthy control group,IMT,plaque index,stiffness,hs-CRP,IL-1,IL-6 and TNF-α in H hypertension and hypertensive groups were significantly increased,but the distensibility were decreased.Also,changes on these indicators of the degree of H-hypertensive group were significantly higher than the hypertension group( P <0.05).Correlation analysis showed that the degree of stenosis of inflammatory cytokines and lipid levels were positively correlated( P <0.05).Multiple regression analysis showed that,Hcy,LDL cholesterol and hs-CRP were risk factors.Conclusion H-hypertensive patients are more prone to stenosis,which is closely related to lipid and inflammatory cytokine levels.

关 键 词：H型高血压 颈动脉狭窄 炎性因子 血脂 

分 类 号：R544.1[医药卫生—心血管疾病]