盐酸氮斯汀对豚鼠实验性哮喘的作用及其机理研究  

Effect of azelastine hydrochloride on experimental asthma and its mechanism in guinea pigs

作　　者：蒋诗琴[1] 余光清[2] 

机构地区：[1]湖北省郧阳医学院药理学教研室 [2]湖北省郧阳医学院学报编辑部

出　　处：《中国临床药理学与治疗学》2004年第1期87-91,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :观察盐酸氮 艹卓 斯汀 (azelastinehydrochlo ride ,AZ)对豚鼠实验性哮喘的作用 ,并探讨其作用机制。方法 :采用组胺和乙酰胆碱诱发在体豚鼠实验性哮喘模型 ,观察AZ的整体作用 ;采用豚鼠离体气管螺旋条 ,观察AZ对组胺所致的豚鼠离体气管螺旋条痉挛的拮抗作用。结果 :AZ能够剂量依赖性地拮抗组胺和乙酰胆碱的引喘作用 ,明显延长引喘潜伏期 ,显著减少抽搐动物发生率 ,其ED50 为 0 .2 16mg·kg-1,95 %可信限为 0 .2 14～ 0 .2 19mg·kg-1。AZ可剂量依赖性地拮抗组胺对离体气管平滑肌的收缩作用 ,使组胺量效曲线平行右移 ,其pA2 值为 8.99。结论 :预先给予AZ能显著拮抗组胺和乙酰胆碱所诱发的在体豚鼠实验性哮喘 。AIM: To probe the effect of azelastine hydrochloride on experimental asthma and its mechanism. METHODS: Experimental asthma models of guinea pigs induced by histamine and acetylcholine in vivo as well as guinea pig tracheal spirals in vitro were used in this experiment. RESULTS: Azelastine hydrochloride inhibited asthma induced by histamine and acetylcholine in guinea pigs in a dose dependent manner, prolonged the incubation period of histamine and acetylcholine induced asthma (P< 0.05 ), and decreased the rate of tic of guinea pigs. The mean effective dose (ED 50 ) was 0.216 mg·kg -1 and its 95% of confidence limit was from 0.214 to 0.219 mg·kg -1 . Azelastine hydrochloride also apparently inhibited the bronchi muscle contraction induced by histamine in a dose dependent manner and caused histamine dose effect curve a right shift, and the pA 2 was 8.99 . CONCLUSION: Azelastine hydrochloride can significantly inhibit the experimental asthma induced by histamine and acetylcholine.

关 键 词：盐酸氮Zhuo斯汀 哮喘 组胺 扑尔敏 豚鼠 

分 类 号：R976[医药卫生—药品] R965[医药卫生—药学]