醒脑静注射液对乙醇所致记忆功能障碍的影响  

Effects of xingnaojing injection on experimental dementia induced by ethanol

作　　者：周红宇[1] 胡国新[1] 胡爱萍[1] 丁细桃[1] 郑荣远[2] 

机构地区：[1]温州医学院药理教研室 [2]浙江神经药物流行病学研究中心

出　　处：《中国临床药理学与治疗学》2004年第1期110-112,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：温州市科技局计划项目 (S2 0 0 2A15 9)

摘　　要：目的 :观察醒脑静注射液 (Xnji)对乙醇所致记忆障碍的改善作用。方法 :乙醇一次给大鼠和小鼠灌服和连续灌服造成学习记忆功能障碍 ,学习记忆的测试采用Morris水迷宫法 ,电迷宫法和避暗法。结果 :Xnji 1.4 ,0 .7ml·kg-1可预防一次性灌服乙醇所致的大鼠空间辨别障碍 ;Xnji 1,2ml·kg-1可治疗连续灌服乙醇所致的小鼠空间辨别障碍和记忆获得障碍。结论 :Xnji可防治急、慢性乙醇中毒所致的学习记忆功能减退。AIM: To observe the effects of xingnaojing (Xnji) injection on learning and memory disorder induced by ethanol. METHODS: The memory impairment was induced by ig ethanol in mice or rats only one time or continuously for 30 days. The Morris water maze, 'Y' maze, and step through methods were used to test the function of learning and memory. RESULTS: Xnji (14,7 ml·kg -1 ) could prevent the impairments of spatial learning ability induced by ethanol given only one time in rats; Xnji (1,2 ml·kg -1 ) could promote spatial learning ability and memory acquisition impaired by ethanol given continuously in mice. CONCLUSION: Xnji can prevent and treat the memory disorder in acute and chronic ethanol intoxication.

关 键 词：乙醇 醒脑静注射液 Morris水迷宫法 学习 记忆 

分 类 号：R285.5[医药卫生—中药学]