术前负荷剂量瑞舒伐他汀对不稳定性心绞痛PCI后心肌损伤的影响  

Effect of preoperative high-dose rosuvastatin on myocardial injury among patients with unstable angina pectoris after percutaneous coronary intervention(PCI)

作　　者：李现立[1] 郑晓晖[1] 胡丰朝[1] 

机构地区：[1]河南省安阳地区医院,河南安阳455000

出　　处：《慢性病学杂志》2015年第3期275-276,280,共3页Chronic Pathematology Journal

摘　　要：目的评价术前负荷剂量瑞舒伐他汀对不稳定性心绞痛经皮冠状动脉介入治疗(PCI)术后心肌损伤的影响。方法将89例不稳定性心绞痛患者随机分为治疗组45例和对照组44例,对照组PCI术前予常规改善心肌缺血、抗凝、抗栓治疗,治疗组在PCI术前12 h口服瑞舒伐他汀20 mg,两组术后均给予瑞舒伐他汀10 mg,每晚一次口服。观察两组PCI术前后高敏C反应蛋白(hs-CRP)、心肌肌钙蛋白I(cTnI)和肌酸激酶同工酶(CK-MB)的变化及术后30 d内主要心血管事件发生例数。结果 PCI术后两组血清hs-CRP、cTnI和CK-MB水平明显升高,但治疗组低于对照组,差异均有统计学意义(P<0.05)。治疗组主要不良心血管事件发生率为8.89%,对照组为27.27%,差异有统计学意义(P<0.05)。结论不稳定性心绞痛PCI术前应用负荷量瑞舒伐他汀减轻围手术期炎症反应和心肌损伤。Objective To observe the effect of preoperative high—dose rosuvastatin on myocardial injury among patients with unstable angina pectoris after percutaneous coronary intervention(PCI).Methods89 patients with unstable angina pectoris were randomly divided into 2 groups:45 patients in treatment group and 44 patients in control group.Patients in control group were treated with routine treatments including improving myocardial ischemia therapy,anticoagulant therapy,and antithrombotic therapy.For patients in treatment group,oral administration of 20 mg rosuvastatin was took place 12 hours before PCI.10 mg of rosuvastatin was used daily after PCI among patients in both groups.Patients were followed for 30 days.The levels of high—sensitivity C—reactive protein(hs— CRP),cardiac Troponin—I(cTnl),and Creatine Kinase—MB(CK—MB) were measured within 30 days after PCI in both groups.Cardiac events were observed among patients too.Results The levels of hs—CRP,cTnI,and CK—MB were elevated significantly 24 hours after PCI among patients in both groups,but the average levels of patients from control group were higher than those from treatment group(P<0.05).The incidence rate of major adverse cardiovascular events was 8.89%in treatment group and 27.27%in control group,and the difference was statistically significant(P<0.05).Conclusions Preoperative high—dose rosuvastatin therapy is effective in reducing the occurrence of perioperative inflammatory response and myocardial injury after PCI in patients with unstable angina pectoris.

关 键 词：心绞痛 瑞舒伐他汀 经皮冠状动脉介入治疗 心肌酶谱 

分 类 号：R541.4[医药卫生—心血管疾病]