抗HLA和MICA抗体对肾移植患者移植肾功能的影响研究  

The effect of anti-HLA and MICA antibody on graft function in patients underwent kidney transplants

作　　者：康颖[1] 贾保祥[1,2] 贾业军 徐秀红 刘杰 单小燕 

机构地区：[1]首都医科大学附属北京友谊医院泌尿科,北京100050 [2]北京诺诗康瀛医学科技有限公司移植免疫研究中心,北京102200 [3]北京市血液中心,北京100088

出　　处：《实用器官移植电子杂志》2015年第6期350-353,共4页Practical Journal of Organ Transplantation(Electronic Version)

基　　金：国家火炬计划项目:2014GH010024

摘　　要：目的研究肾移植术后抗人类白细胞抗原(HLA)和组织相容性复合物Ⅰ类链相关分子A(MICA)抗体对移植肾长期存活的影响。方法选择了首都医科大学附属北京友谊医院78例可追踪到的肾移植术后的患者于2014年10月检测患者群体反应性抗体(PRA)和MICA抗体。血肌酐和尿素氮检测数据由检验科提供。结果 78例肾移植患者中抗HLA抗体和MICA抗体阳性的患者62例,其中肾功能正常患者14例,肾功能下降或丧失患者48例;抗HLA抗体和MICA抗体阴性患者16例,其中肾功能正常患者5例,肾功能下降或丧失患者11例。结论抗HLA和MICA抗体是影响移植肾长期存活的重要因素之一。Objective To study long-term effects of anti-HLA and anti-major histocompatibility complex class I chain-related molecule A(MICA) antibodies after kidney transplantation on renal allograft .Methods A total number of78 cases in Beijing Friendship Hospital, Capital Medical University which can be traced were selected after renal transplantation in October2014. Panel reactive antibody(PRA) and MICA antibodies were detected. Serum creatinine and blood urea nitrogen test data were provided by the clinical laboratory.Results Among these 78 cases of patients, Anti-HLA antibody and MICA antibodies were positive in62 cases, There were14 patients with normal renal function, the decrease graft function or graft loss were observed in48 patients; There were16 cases of Anti-HLA and MICA negative patients, of which5 cases in patients with normal renal function, and patients with decrease graft function or graft loss were11 cases.Conclusion Anti-HLA and MICA antibodies were important factors affecting the long-term survival of transplanted kidney.

关 键 词：肾移植 抗HLA抗体 抗MICA抗体 肾功能 

分 类 号：R699.2[医药卫生—泌尿科学]