亲代谢型谷氨酸受体对基底神经节多巴胺和谷氨酸释放的调节  

Regulation of dopamine and glutamate release by metabotropic glutamate receptors in the basal ganglia motor circuit:implications for treatment of parkinsons disease

作　　者：孟长虹[1] 胡刚[1] 

机构地区：[1]南京医科大学药理学与神经生物学系，南京210029

出　　处：《中国药理学通报》2003年第7期741-745,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题 ;No 39970 84 6

摘　　要：亲代谢型谷氨酸受体 (metabotropicglutamaterecep tors,mGluRs)是一类与G蛋白偶联的调节离子通道和第二信使生成酶的新型谷氨酸受体 ,在基底神经节 (basalganglia ,BG)分布非常广泛。分布于BG的各亚型mGluRs受体能够调节多巴胺 (dopamine ,DA)和谷氨酸 (glutamate,Glu)的释放 ,其调节效应与脑区、受体亚型以及药物浓度等相关。Metabotropic glutamate receptors (mGluRs) are a family of G protein coupled receptors linked to modulation of ion channel functions and multiple second messengers. These receptors are widely distributed throughout the basal ganglia (BG). Studies have demonstrated that these mGluRs subtypes located at various synapses in BG could modulate the release of dopamine and glutamate which correlates with brain area,the subtype selectivity and concentration of the ligands. Metab otropic glutamate receptors have been proposed as potentially new therapeutic targets for Parkinsons disease by providing a method of pharmacologically regulating neurotransmission in the BG.

关 键 词：亲代谢型谷氨酸受体 基底神经节 帕金森病 多巴胺 谷氨酸 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R341[医药卫生—基础医学]