多孔磷酸三钙陶瓷人工骨在体内的新陈代谢过程研究  

STUDY ON THE METABOLIC PROCESS OF POROUS β-TRICALCIUM PHOSPHATE CERAMICS IN VIVO

作　　者：戴红莲[1] 李世普[1] 闫玉华[1] 卢旭辉[1] 江昕[1] 郑启新[2] 杜靖远[2] 

机构地区：[1]武汉理工大学生物材料与工程研究中心,武汉430070 [2]华中科技大学同济医学院骨科,武汉430022

出　　处：《硅酸盐学报》2003年第12期1161-1165,共5页Journal of The Chinese Ceramic Society

基　　金："973"国家重点基础研究发展规划(G1999064701)资助项目

摘　　要：选择放射性同位素45Ca作为示踪剂,研究了β-磷酸三钙基多孔陶瓷人工骨在体内降解后所产生的Ca2+的代谢途径。结果表明:β-磷酸三钙陶瓷人工骨在动物体内的部分降解产物进入血液参加循环,到达肝、肾、脑、心、肺、脾、胃等脏器及组织中进行代谢,且不发生积累,不造成脏器组织的损害及病理性钙化。一部分Ca2+进入股骨近端,尺骨干及颅骨中被机体重新利用,参与全身生命骨组织的钙化或被储存于“钙库”(骨组织)中。在循环过程中,还有一部分Ca2+经过肾和肠进入尿和粪,并通过尿和粪排泄出体外。可见钙磷可降解陶瓷人工骨,降解后的产物可参与机体正常的生理代谢过程。The metabolic way of calcium ions, which are produced by porous β-TCP (β-tricalcium phosphate) ceramics degraded in vivo was studied by using the radioisotope 45Ca as tracer. The result shows that some of the calcium ions, which are released from β-TCP ceramics due to degradation, enter into blood and take part in its circulation. These calcium ions are distributed in organs and tissues such as liver, kidney, brain, heart, lung, spleen and stomach, and then participate in their metabolism. There is no accumulation of calcium ions, and there is not any lesion or pathologic calcification of the organs and tissues. Some of the calcium ions, which enter into the proximal femur, ulna and skull, are reused by bony tissue to take part in both local mineralization processes during bone healing or are stored in calcium pool, which can participate the circulating of whole body. In the cyclical process, parts of calcium ions are excreted with urine and dung through kidney and liver. It is indicated that the degradation products of β-TCP ceramics can take part in the activity of life.

关 键 词：多孔磷酸三钙陶瓷 体内示踪 新陈代谢 

分 类 号：R318.08[医药卫生—生物医学工程]