4'-氧代乙酸-7-羟乙氧基-葛根黄豆苷元的小鼠体内分布研究  

Distribution of 4′-oxo-acetic acid-7-hydroxyethoxy-daidzein in mice

作　　者：姜铁夫[1] 陈济民[2] 佟志清[1] 王永华[1] 李媛[1] 

机构地区：[1]中国人民解放军第463医院药剂科,沈阳110042 [2]沈阳药科大学药剂学教研室,沈阳110016

出　　处：《药学服务与研究》2003年第4期237-239,共3页Pharmaceutical Care and Research

基　　金：国家新药研究基金资助课题(No.969010555)

摘　　要：目的:制备合成了葛根4′-氧代乙酸-7-羟乙氧基-黄豆苷元(DZ18),研究DZ18在小鼠体内的分布。方法:采用HPLC法研究了DZ18静注后小鼠体内的脏器分布规律,对DZ18的血浆蛋白结合率进行了考察。结果:DZ18在心、脑、肝中浓度比较高,DZ18的血浆蛋白结含率随药物浓度的增加而减少。结论:该药主要分布在心、脑等器官,有利于发挥其治疗心脑血管疾病的作用。Objective: To prepare and study the distribution of Radix Puerariae 4′-oxo-acetic acid-7-hydroxyethoxy-daidzein (DZ18) in mice tissues. Methods: After iv DZ18 60 mg/kg in mice, the concentrations of DZ18 in tissues were determined by HPLC method. Results: The analysis results showed that concentration of DZ18 was highest in heart, followed by liver. The plasma-protein binding rate decreased with increasing concentration of DZ18. Conclusion: According to the distribution of DZ18 in mouse tissues, it is good for treating vascular diseases of heart and brain.

关 键 词：葛根黄豆苷元 DZ18 分布 色谱法 高压液相 

分 类 号：R972[医药卫生—药品]