电刺激大鼠岛叶对心电图和心率变异性的影响  

Effects of Electric Stimulating Insular Cortex of Rat on ECG and Heart Rate Variability

作　　者：王艺明[1] 刘兴德[2] 董为伟[3] 杨宗城[1] 

机构地区：[1]重庆第三军医大学西南医院烧伤研究所,重庆400038 [2]贵阳医学院附属医院心内科 [3]重庆医科大学附属第一医院神经内科

出　　处：《中国医师杂志》2003年第12期1605-1607,共3页Journal of Chinese Physician

基　　金：国家自然科学基金资助项目 (39370 2 61 )

摘　　要：目的　探讨电刺激大鼠岛叶对心脏心电图、心率变异性 (heartratevariability ,HRV)的影响。方法　将 3 6只健康雄性大鼠随机分成 2组 ,对照组及岛叶刺激组 ,每组 18只 ,用 5 0 0 μA、5 0HZ电流刺激大鼠岛叶 1h后 ,观察大鼠的ECG变化 ;将 42只健康雄性大鼠随机分成 3组 ,假手术组、对照组、岛叶刺激组 ,其中对照组与岛叶刺激组又分为 70uA、5 0 0uA、15 0 0uA ,5 0HZ刺激组 ,每组 6只 ,刺激大鼠岛叶 1h后 ,观察大鼠的血压、心率、HRV参数值。结果　 5 0 0uA电流刺激后 ,岛叶刺激组的ECG发生变化 ,并且血压、心率较假手术组、对照组明显升高 ,差异有显著性 ;70uA、5 0 0uA、15 0 0uA电刺激岛叶皮质时 ,5 0 0uA、15 0 0uA刺激组的HRV的参数值降低 ,即均方根值 (squarerootofthemeansquareddifferencesofsuccessiveNNintervals ,RMSSD)、相邻心搏间期差 >10ms的间期数占RR间期总数的百分比、总频、高频、低频、混沌参数均降低 ,而低频 /高频升高 ,与 70uA刺激组及相应对照组比较 ,差异有显著性 ,提示心脏副交感神经活性降低 ,交感神经活性增强 ,且 15 0 0uA刺激组较 5 0 0uA刺激组HRV的各项指标降低更明显。结论　提示病理生理性岛叶激活如卒中、癫痫发作及一些严重应激等 ,可导致心脏的ECG、血压、心率、?Objective To assess the effects of electric stimulating insular cortex on ECG and heart rate variability(HRV) in rats. Methods ⑴The total of 36 healthy male Wistar rats were randomly divided into control group and electric stimulating group, and ECG was observed after electric stimulating insular cortex 1 hour with 500uA,50HZ current intensity. ⑵The total of 42 healthy male Wistar rats were randomly divided into sham group,control group and electric stimulating group, then the control group and electric stimulating group were further divided into 70uA,500uA,1500uA,50HZ stimulating groups, each group containing 6 rats. Blood pressure, heart rate and HRV were observed after electric stimulation 1 hour. Results ⑴The ECG showed change,and heart rate and blood pressure of rats in the electric stimulating group significantly increased at 500uA after electric stimulation 1 hour compared with sham and control groups. ⑵The measured components of HRV of 500uA and 1500uA stimulating groups, such as percentages of NN intervals differences<10(PNN10), square root of the mean squared differences of successive NN intervals(RMSS), total power (TP), low frequency power (LF), high frequency power (HF) and fractal dimension (FD) significantly decrease, and LF/HF significantly increased at 70uA,500uA,1500uA electric stimulating insular cortex compared with control group. The measured components of HRV were more lower in 1500uA electric stimulating group than those in 500uA electric stimulating group. Conclusions The data suggested that pathophysiological activation of the insular cortex by stroke,epileptic seizure or under conditions of severe stress can conduct significant changes of ECG, heart rate, blood pressure and HRV. We must enforce view on ECG, heart rate, blood pressure and HRV to prevent cerebrogenic sudden death.

关 键 词：电流刺激 大鼠 岛叶 心率变异性 心电图 脑卒中 

分 类 号：R540.41[医药卫生—心血管疾病]