4-(1-苯乙基氨基)-6-硝基喹唑啉的简便合成方法  

Synthesis of 4-(1-phenylethylamino )-6-nltro-quinazoline

作　　者：陈惠[1] 孙晓莉[1] 张生勇[1] 姜茹[1] 

机构地区：[1]第四军医大学化学教研室,陕西西安710032

出　　处：《化学试剂》2003年第6期359-360,共2页Chemical Reagents

基　　金：国家自然科学基金资助项目(20272082)

摘　　要：4-氯-6-硝基喹唑啉与α-甲基苄胺在异丙醇等6种溶剂中,经回流可生成4-(1-苯乙基氨基)-6-硝基喹唑啉,反应可在1.5～2h内完成。通过对产物进行柱层析分离,纯品产率为85.7％,并对产物进行了波谱表征。4-Chloro-6-nitro-quinazoline reacted with 1-phenylethylamine in the presence of iso-propanol or other solvents under refluxing. The yellow product of 4-(1-phe-nylethylamino)-6-nitro-quinazoline was obtained after 1.5 to 2 hours. The product was purified by column chroma-tography with a yield of 85. 7%. Its structure was confirmed by NMR and infrared spectra.

关 键 词：4—(1—苯乙基氨基)—6—硝基喹唑啉 合成 酪氨酸激酶抑制剂 中间体 表皮生长因子 溶剂 

分 类 号：TQ463.54[化学工程—制药化工]