特发性脊柱侧凸的病因学研究:鸡脊柱侧凸模型椎旁肌中肌梭的形态学特征  

An etiology study on idiopathic scoliosis:morphologic character-istics of muscle spindle in paraspinal muscle of the chicken sco-liosis model

作　　者：王善松[1] 李明[1] 朱晓东[1] 陈语[1] 

机构地区：[1]解放军第二军医大学长海医院骨科,上海市200433

出　　处：《中国临床康复》2004年第2期280-281,T006,共3页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科学基金(30271440);上海市科技启明星跟踪计划基金(2002QB1403)~~

摘　　要：目的:观察鸡脊柱侧凸模型椎旁肌中肌梭结构、数量、密度及其分布,为特发性脊柱侧凸的病因提供理论依据。方法:对刚孵育出的鸡行松果体切除,获得脊柱侧凸动物模型;将鸡脊柱侧凸模型分为Cobb角10°～20°组及Cobb角>40°组,椎旁肌取下后切片,行Masson三色染色,观察肌梭结构,对肌梭数量、密度进行统计学分析。结果:鸡脊柱侧凸模型椎旁肌中部分肌梭被囊呈“气球样变”,梭内肌纤维有异常改变;Cobb角10°～20°组肌梭密度为(25±5)个/g肌肉。Cobb角>40°组肌梭密度为(23±7)个/g肌肉。结论:与正常对照组相比,鸡脊柱侧凸模型椎旁肌中部分肌梭结构异常,肌梭数量减少,密度降低。AIM:To study the structure,number,density and distribution of muscle spi ndle in paraspinal muscle of the c hicken scoliosis model so as to provi de theo retical basis for the pathogeny of idiopathic scoliosis METHODS:The scoliosis m odel obtained by performing pinealectomy in chickens(3days old)was divided in to two groups accordin g to Cobb degree:Cobb 10°-20°group and Cobb >4 0°goup.After the paraspinal muscle were obtained,they were cut into pie ces .Morphology of the spindle using Masson trichrome stain.Statistical analysis w ere performed on the numb er and density of muscle spindle.RESULTS:In some of the spindles in paraspinal muscle of model,the membranes showed'changing like balloon',and the intrafusal muscle fiber was irregular.The density of muscle spindle was(25±5)in Cobb 10°-20°group and(23±7)per gram of m uscle in Cobb >40°group.Compared with the control group,the st ructure of some of the spindles in paraspinal muscle of the chicken scoliosis m odel is irregular,the number is fewer and density is decreased.

关 键 词：病因学 脊柱侧凸 椎旁肌 肌梭 形态学 鸡 神经纤维 

分 类 号：R681.5[医药卫生—骨科学] R-332[医药卫生—外科学]