常见革兰阴性杆菌对第三代头孢菌素的耐药率比较  

Comparison of resistance of the common Gram-negative bacilli to the third cephalosporins

作　　者：易霞云[1] 郭思健[1] 李宪[1] 张晋湘[1] 李洁[1] 

机构地区：[1]中南大学湘雅医院,湖南长沙410008

出　　处：《中国感染控制杂志》2004年第1期24-26,共3页Chinese Journal of Infection Control

摘　　要：目的　了解常见革兰阴性杆菌对第三代头孢菌素的耐药状况 ,为合理选择抗菌药物提供依据。方法　分别对 1996～ 2 0 0 2年医院细菌室从病房送检标本中分离的前 5位需氧菌对第三代头孢菌素的药敏试验结果进行耐药率统计分析。结果　前 5位革兰阴性杆菌中 ,阴沟肠杆菌对第三代头孢菌素的耐药率均在 5 0 %以上 ,耐药率由高至低依次为阴沟肠杆菌、不动杆菌、铜绿假单胞菌、肺炎克雷伯菌、大肠埃希菌。肺炎克雷伯菌和大肠埃希菌耐药率在 30 %左右 ,相对较低 ,但肺炎克雷伯菌耐药率有逐年增高趋势。结论　动态观察细菌耐药率与临床效果综合评价对临床合理选择抗菌药物有指导意义。Objective To evaluate the resistance of the common Gram-negative bacilli to the third cephalosporins and provide guidance for the choice of antimicrobial agents. Methods The antimicrobial susceptibility of the first five Gram-negative bacilli isolated from a hospital from 1996 to 2002 was analysed. Results Enterobacter cloacae had the highest antimicrobial resistant rate of 50%, followed by Acinetobacter spp, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli. Conclusion Antimicrobial susceptibility test and the evaluation of the effect of antimicrobial agents on clinic are important for the choice of antimicrobial agents.

关 键 词：革兰阴性杆菌 第三代头孢菌素 耐药率 微生物 药敏试验 

分 类 号：R978.1[医药卫生—药品] R969.3[医药卫生—药学]