抑凋亡基因bcl-X_L在胰腺癌组织中的表达及意义  

Expression and significance of bcl-X_L gene in pancreatic carcinoma

作　　者：史朝晖[1] 姜希宏[1] 靳斌[1] 

机构地区：[1]山东大学齐鲁医院,山东济南250012

出　　处：《山东医药》2003年第36期9-10,共2页Shandong Medical Journal

摘　　要：目的　探讨抑凋亡基因 bcl- XL 在胰腺癌组织中的表达及其临床意义。方法　应用免疫组织化学链霉亲和素方法 (SABC) ,检测 5 2例份胰腺癌组织中凋亡抑制基因 bcl- XL 的基因蛋白产物 ,并与良性和正常胰腺组织作对照分析。结果　胰腺癌组织中 bcl- XL 的阳性表达率为 73.1% ,显著高于胰腺良性组织及正常组织 ,bcl-XL 的表达与肿瘤的 TNM分期有关 ,而与肿瘤直径、淋巴结转移、分化程度、病理类型等无关。结论　 bcl- XLObjective To study the expression of bcl-X L gene in pancreatic carcinoma and evaluated its relation with clinical pathology.Method 52 pancreatic carcinoma were studied for protein expression of bcl-X L gene by immunohistochemistry. Results The positive rates of bcl-X L protein in pancreatic carcinoma were 73.1%,and which higher than that of benign and normal pancreatic tissues.The expression of bcl-X L was related to TNM stage,and had no relation with tumor diameter,lymph node metastasis,the extent of differentiation and type of pathology.Conclusion bcl-X L gene may play an important role in pancreatic tumorigenesis.

关 键 词：抑凋亡基因 BCL-XL 胰腺癌 癌组织 基因表达 

分 类 号：R735.9[医药卫生—肿瘤] R394[医药卫生—临床医学]