河北省丙型肝炎病毒基因分型研究  

Genotyping of Hepatitis C Virus in Hebei Province

作　　者：牛建章[1] 许若丹[1] 白瑞婷[2] 田茶[2] 张立平[1] 孟宗达[2] 

机构地区：[1]河北大学生命科学学院,河北保定071002 [2]河北省疾病预防控制中心,河北石家庄050011

出　　处：《中国病毒学》2003年第6期611-613,共3页Virologica Sinica

基　　金：河北省医学重点跟踪项目(99037)

摘　　要：丙型肝炎病毒 (Hepatitis C virus, HCV)感染是输血后肝炎的主要原因[1],主要通过输血或使用污染的血制品传播[2],且与肝硬化和肝细胞癌的发生有密切关系.Using nested RT-PCR and type special primers of HCV, we performed genotype analysis of HCV RNA from five representative cities in Hebei Province. Among 168 samples with HCV RNA, 104 sera was typelb(61.9%), type 2a account for 22.6% (38/168) , and Ib/2a mixed-type was 15.5% (26/168) . The results indicate that typelb is the dominance strain in Hebei Province. Compared with type 2a, typelb has important relationship with chronic hepatitis C. This study build up some foundations for diagnosis, treatment and vaccine study of hepatitis C.

关 键 词：丙型肝炎病毒 基因分型 巢式RT—PcR 基因序列 

分 类 号：R446.5[医药卫生—诊断学]