A study on indirect radiolabeling of IgG with carrier free ^(188)Re  

作　　者：ZHANG Xiu-Li, WANG Yong-Xian, LI Jun-Ling, YIN Duan-Zhi (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) 

出　　处：《Nuclear Science and Techniques》2003年第2期131-134,共4页核技术（英文）

基　　金：Supported partially by Key Project of Knowledge Innovation Program of the Chinese Academy of Sciences(KJCX1-SW-08)

摘　　要：188Re labeled monoclonal antibodies are potential candidates for use in radioimmunotherapy. S-Bz-MAG3 as a bifunctional chelating agent was used for labeling of IgG with carrier free 188Re by pre-radiolabeling of the chelating approach. The conjugation conditions were optimized. The stability of 188Re-MAG3-IgG in vitro was high. The results may be useful to the studies of 188Re labeled MAbs for radioimmunotherapy.188Re labeled monoclonal antibodies are potential candidates for use in radioimmunotherapy. S-Bz-MAG3 as a bifunctional chelating agent was used for labeling of IgG with carrier free 188Re by pre-radiolabel-ing of the chelating approach. The conjugation conditions were optimized. The stability of 188Re-MAG3-IgG in vitro was high. The results may be useful to the studies of 188Re labeled MAbs for radioimmunotherapy.

关 键 词：^188RE 铼 单克隆抗体 放射免疫性疗法 

分 类 号：R817[医药卫生—影像医学与核医学]