手术后放疗加口服积雪甙治疗瘢痕疙瘩的临床研究  

Treatment of Keloid with Centella Tripterpenes After Surgical Excision and X-Ray Irradiation

作　　者：赵亮[1] 方方[1] 王焱[1] 吴信峰[1] 王强[1] 陈晓栋[1] 龚向东[1] 张国成[1] 

机构地区：[1]中国医学科学院,中国协和医科大学皮肤病研究所,南京210042

出　　处：《中华皮肤科杂志》2003年第6期342-344,共3页Chinese Journal of Dermatology

摘　　要：目的比较3种联合疗法治疗瘢痕疙瘩的效果,同时探讨积雪甙对瘢痕疙瘩的治疗作用。方法在外科手术切除术后予以浅层X线放疗的基础上,将106例瘢痕疙瘩患者随机分成使用积雪甙的高剂量组和低剂量组,以及使用安慰剂的对照组进行研究。结果所有患者手术切口均甲级愈合,使用积雪甙的治疗组75例患者痊愈率33.3%,有效率86.7%;对照组31例患者的痊愈率12.9%,有效率48.4%。Ridit方法分析:2个治疗组疗效明显优于使用安慰剂的对照组(P<0.01和P<0.05),而使用积雪甙片的2个治疗组之间差异无显著性(P>0.05)。结论手术、放射结合积雪甙片治疗瘢痕疙瘩效果可靠,且无明显的副作用。Objective To validate the therapeutic effect of Centella Triterpenes after surgical excision and X-ray irradiation.Methods Surgical excision was performed on one hundred and six patients with keloid,after operation superficial X-ray irradiation was given to the patients.Then,they were divided into three groups:36cases in group A treated with higher dose of Centella Triterpenes;39cases in group B treated with lower dose of Centella Triterpenes;31cases took placebo as controls.All patients were followed up for12months after treatment.Results All patients were healed completely after operation.The effective rate was significantly higher in Centella Triterpenes groups than that in the control group(P<0.01).No significant difference was found between the effective rates of group A and group B.Conclusions Combination therapy with centella Triterpenes surgical operation and superficial X-ray irradiation is effective in treating keloid with mild adverse reactions.

关 键 词：积雪甙 瘢痕疙瘩 临床研究 联合疗法 手术治疗 放射疗法 安慰剂 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]