川芎嗪对犬肾动脉成形术局部血栓形成影响的实验研究  

Experimental study of effect of ligustrazine on the thrombosis of PTRA site in canine renal artery stenosis model

作　　者：梁俊生 贺能树[2] 吴胜勇[2] 杨海贤[3] 

机构地区：[1]承德市解放军第266医院放射科,河北067000 [2]天津医科大学总医院放射科 [3]天津医科大学电镜中心

出　　处：《放射学实践》2003年第10期757-759,共3页Radiologic Practice

摘　　要：目的 :探索川芎嗪对预防PTA后血栓形成的作用。方法 :15只杂种犬 ,随机分为对照组、川芎嗪组和阿司匹林组 ,每组 5只。狭窄术 6～ 8周后行PTRA。术后 4h将动物处死 ,处死前切取成形肾动脉 ,制作光、电镜标本。利用图像分析软件测量PTRA局部血栓体积和分析血小板血栓的超微结构。结果 :两个实验组PTRA局部血栓明显小于对照组 ,PTRA局部血小板血栓单位面积内纤维蛋白面积、血小板和线粒体数量均显著低于对照组 ,而α 颗粒、致密颗粒的相对数量明显高于对照组 ;两个实验组间上述指标差异均无显著性意义。结论 :川芎嗪可能是一种有效预防PTA后血栓形成的药物。Objective:To evaluate the effect of ligustrazine on preventing the thrombosis at the site of percutaneous transluminal renal angioplasty (PTRA).Methods:Dogs models (n=15) with experimental renal stenosis were selected and randomly divided into control group,ligustrazine group and aspirin group.Each group had five dogs.PTRA were performed 6～8 weeks after experimental renal stenosis.All dogs were killed 4 hours after PTRA.Angioplastic renal arteries were removed before dogs were killed.Renal specinens were fixed for light and electron microscopic analysis.The thrombus volume and microstructure of platelet thrombus at PTRA sites were measured and analysed respectively.Results:The thrombus volume of the two experimental groups were significantly smaller than that of the control group.Compared with the two experimental groups,the fibrin area were significantly high,the gap area were significantly low in the white thrombus in the control group;the number of platelet and thread granules were evidently high,but relative number of α granules and compact granules were significantly low in the control group.Compared with each other,the changes of the thrombus volume of PTRA sites,the fibrin and gap area in the white thrombus,the number of platelets and thread granules,relative number of α granules and compact granules were not statistically significant in two experimental groups.Conclusion:Ligustrazine could be one of the effective drugs in preventing thrombosis after PTA.

关 键 词：川芎嗪 肾动脉成形术 局部血栓形成 实验研究 

分 类 号：R285[医药卫生—中药学]