20例乙型肝炎病毒相关肾炎的临床和病理分析  

Clinical and pathological analysis of hepatitis B virus-associated glomerulonephritis in 20 cases

作　　者：陈慧敏[1] 卫敏江[1] 

机构地区：[1]上海第二医科大学附属新华医院,上海200092

出　　处：《实用儿科临床杂志》2004年第1期21-22,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的　探讨乙型肝炎病毒相关肾炎 (HBV GN)的临床和病理。方法　 2 0例HBV GN ,临床表现肾病综合征 17例 ,其中单纯性肾病 4例 ,肾炎性肾病 13例 ;单纯性蛋白尿 2例 ;肾炎综合征 1例。结果　肾活检病理诊断膜性肾炎 (MN) 15例 ,膜增生性肾小球肾炎 (MPGN) 3例 ,系膜增生性肾小球肾炎 (MsPGN) 2例。平均随访 5 .7年。 2 0例中 8例应用重组人α 干扰素治疗 ,5例完全缓解 ,3例HBsAg、HBeAg转阴 ,1例HBeAg转阴并出现抗HBe ;2例部分缓解 ;1例无效。结论　HBV GN病理以MN为主 。Objective To understand the clinical and pathological features of hepatitis B virus-associated glomerulonephritis(HBV-GN).Methods Twenty children with HBV-GN were analysed including 17 cases of nephritic syndrome (4 cases of simple nephrosis, 13 cases of nephritic nephrosis),2 cases of isolated proteinuria, 1 case of nephritic syndrome according to the clinical classification.Results On the basis of pathology of kidney biopsy, there were 15 cases of membranous glomerulonephritis(MN),3 cases of manbranoproliferative glomerulonephritis(MPGN),2 cases of mesangial proliferative glomerulonephritis(MsPGN).Eight of 20 cases were treated with recombinated human alpha-interfeon. The average follow-up time was 5.7 years. As the result, complete remission clinically was on 5 cases,partial remission on 2 cases and ineffectiveness on one case. Besides, serum HBsAg, HBeAg were converted to negative on 3 cases , HBeAg disappeared and anti-HBe appeared on one case.Conclusion MN is common in childhood with HBV-GN.It also indicates the prognosis of the associated nephropathies is quite favorable.

关 键 词：乙型肝炎病毒相关肾炎 肾病综合征 肾活检 

分 类 号：R726.9[医药卫生—儿科]