葛根素对高血压病病人气管插管期心血管反应的影响  

Puerarin for the control of cardiovascular responses to tracheal intubation in patients with hypertention

作　　者：吴先平[1] 冯俊光 冯丽容 陈浩铭[1] 

机构地区：[1]广东省佛山市顺德中西医结合医院

出　　处：《中西医结合心脑血管病杂志》2004年第1期19-20,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：广东省中医药管理局立项项目 (No .40 30 4 1 )

摘　　要：目的 :探讨葛根素注射液控制高血压病病人插管期心血管反应的有效性。方法 :3 0例原发性高血压全麻病人 ,随机均分为葛根素组 (P组 )和对照组 (C组 ) ,分别于诱导前 1h静脉输注中药葛根素注射液 5 0 0mg或不用降压药 ,观察插管期收缩压 (SBP)、舒张压 (DBP)、心率 (HR)、平均动脉压 (MAP)和心率收缩压乘积 (RPP)。结果 :与诱导前比较 ,两组诱导后SBP、DBP、MAP均明显下降 (P <0 .0 1) ;C组插管时及插管后等时段SBP、DBP、MAP、HR及RPP均明显增加 (P <0 .0 1或P <0 .0 5 ) ;P组插管时及插管后 1minSBP、DBP、MAP均有不同程度下降 (P <0 .0 1或P <0 .0 5 ) ,HR及RPP未见明显变化。与C组比较 ,P组插管时及插管后 1min、3min等时段SBP、HR及RPP均显著降低(P <0 .0 1或P <0 .0 5 )。结论 :中药葛根素注射液静脉输注能有效控制插管刺激引起的心血管反应 ,有助于高血压病病人插管期维持血流动力学相对稳定。Objective:To study the effectiveness of Puerarin on controlling the cardiovascular responses to tracheal intubation in patients with hypertention. Methods:30 patients with hypertention undergoing general anesthesia were devided into control group (C, without depressor, n=15) and Puerarin group (P, 500 mg, n=15). The SBP, DBP, MAP, HR and RPP were measured during the induction of general anesthesia and intubation respectively. Results:The SBP, DBP, MAP, HR and RPP increased markedly in group C after intubation (P<0.01～P<0.05), but the SBP, DBP and MAP decreased markedly(P<0.01～P<0.05) and HR, RPP remained stable in group P; compared with group C, there were significant difference in same period during tracheal intubation respectively in group (P<0.01～P<0.05). Conclusion:Puerarin can reduce cardiovascular responses to tracheal intubation effectively, and be helpful in keeping the hemodynamic stability, especially in patients with hypertention.

关 键 词：高血压病 气管插管期 心血管反应 葛根素注射液 中药制剂 

分 类 号：R614[医药卫生—麻醉学]