重型乙型肝炎的病毒复制状况与病情的关系  

Relationship between Hepatitis B Virus Replication in Severe Hepatitis B and Severity of the Illness

作　　者：岳峰[1] 刘婕[1] 沈敦[1] 邓同美[1] 

机构地区：[1]洛阳医学高等专科学校附属医院传染科,洛阳市471003

出　　处：《医药论坛杂志》2003年第10期10-11,共2页Journal of Medical Forum

摘　　要：目的　了解重型乙型肝炎时乙型肝炎病毒 (HBV)的复制状况及其与病情的关系。方法　应用酶联免疫吸附实验和聚合酶链反应测定 172例乙型肝炎病人的HBV复制指标。结果　慢性重型肝炎病人的HBeAg和 /或HBVDNA阳性率明显低于非重型慢性肝炎 (P <0 0 1) ;HBV复制状态与血清转氨酶、总胆红素水平及预后无明显相关性。结论　HBV复制活跃不一定是重型肝炎发生的因素。Objective In order to elucidate the relationship between hepatitis B virus(HBV) replication in severe hepatitis B and the severity of the illness.Methods HBV serological markers and HBV DNA in 172 patients with chronic hepatitis B were detected using the methods of ELISA and PCR,respectively.Results The positive prevalence of HBeAg and/or HBV DNA in chronic severe hepatitis B was much lower the level of ALT,TB and the prognosis(P<0 01).Conclusion Increased replication of HBV appears to be not the cause of hepatic necrosis in severe hepatitis B.

关 键 词：重型乙型肝炎 病毒复制 病情 预后 酶联免疫吸附实验 聚合酶链反应 转氨酶 总胆红素 

分 类 号：R512.62[医药卫生—内科学]