代谢综合征的颈动脉粥样硬化特征  

The characteristics of carotid atherosclerosis in metabolic syndrome

作　　者：赵志钢[1] 祝之明[1] 李彦社[1] 

机构地区：[1]第三军医大学大坪医院高血压内分泌科

出　　处：《中华内科杂志》2003年第9期625-627,共3页Chinese Journal of Internal Medicine

基　　金：国家自然科学基金资助项目 (3 972 5 0 13 )

摘　　要：目的　观察代谢综合征患者颈动脉形态和功能的变化特点。方法　 171例住院病人分为代谢综合征组 (MS ,84例 ) ,高血压病组 (EH ,6 8例 )、糖尿病组 (DM ,19例 ) ,比较三组患者血脂改变及颈动脉超声检测结果。结果　MS组患者血浆甘油三酯 (TG)、低密度脂蛋白、载脂蛋白B水平较EH组明显升高 ( 2 5 3± 2 15比 1 72± 1 6 6 ,3 2 7± 0 99比 2 91± 0 92 ,1 0 7± 0 2 6比 0 97±0 2 0 ,P <0 0 1,0 0 5 ,0 0 1) ,MS组TG水平明显高于DM组 ( 2 5 3± 2 15比 1 6 7± 0 89,P <0 0 1) ;与EH、DM组比较 ,MS组患者颈动脉系血流阻力指数明显升高 ,颈总动脉内膜明显增厚 ( 0 88± 0 2 2比 0 80± 0 2 4 ,0 88± 0 2 2比 0 72± 0 2 9,P值均 <0 0 5 ) ;MS组颈动脉粥样斑块发生率及斑块指数明显升高。Objective To study the structure and function of the carotid artery in the metabolic syndrome ( MS ).Methods 171 patients were divided into three groups: metabolic syndrome(MS), diabetes millitus(DM), and essential hypertension(EH). Plasma lipids and ultrasonography for carotid artery were examined.Results Levels of TG 、LDL、ApoB were significantly higher in MS as compared with those EH( P <0.01,0.05,0.01). Levels of TG were higher in MS as compared with those in DM( P <0 01). The carotid resistance index and the intima media thickness (IMT) of common carotid artery were significantly higher in MS as compared with those in DM or EH ( P <0.05). The occurrence rate of carotid plaque and plaque index was higher in patients with MS than that in patients with EH or DM ( P <0 01,0 01).Conclusion Clustering of multiple cardiovascular risk factors can cause more severe atherosclerosis of carotid artery in MS.

关 键 词：代谢综合征 颈动脉粥样硬化 血脂 大血管损害 超声检测 冠心病 

分 类 号：R58[医药卫生—内分泌]