光学活性R-2-羟基-4-苯基丁酸乙酯的制备  

Synthesis of the Optical Active Compound of R-2-hydroxy-4-phenyl ethyl butyrate

作　　者：李立新[1] 李军[1] 谢明贵[1] 

机构地区：[1]四川大学化学学院,四川成都610064

出　　处：《四川大学学报（工程科学版）》2003年第4期106-108,共3页Journal of Sichuan University (Engineering Science Edition)

摘　　要：R-2-羟基-4-苯基丁酸乙酯是制成血管紧张素转化酶抑制剂类药物的重要中间体,以廉价易得的DL-苹果酸为手性源,经过酐活化、付-克反应、拆分、常压催化氢解和酯化等成功地制得了R-2-羟基-4-苯基丁酸乙酯,为了工业化生产制备该类药物提供了一些可行的方法和途径。R-2-hydroxy-4-phenyl ethyl butyrate is an important intermediate of an angiotension converting enzyme inhibitor. R-2-hydroxy-4-phenyl butyric acid and its ethyl ester was synthesized with DL-malic acid as starting material by a series reation, such as enzyme activity, resolution, Frieded-Crafts reaction, hydrogenolysis, esterification in general pressure. The study provided a practicable method for industrial production of this remedy. 

关 键 词：光学活性 拆分 包结拆分 不对称合成 R-2-羟基-4-苯基丁酸乙酯 

分 类 号：O623.624[理学—有机化学]