辛可尼定修饰的铂纳米簇合物催化丙酮酸甲酯不对称加氢反应的研究  

Studies on the Enantioselective Hydrogenation of Methyl PyruvateCatalyzed by γ-Al_2O_3 Supported Platinum Nanoclusters

作　　者：黄艳轶[1] 马红霞[1] 熊伟[1] 陈华[1] 李贤均[1] 

机构地区：[1]四川大学化学学院有机金属络合催化研究所,四川成都610064

出　　处：《分子催化》2003年第6期409-413,共5页Journal of Molecular Catalysis(China)

摘　　要：研究了辛可尼定(cinchonidine)作手性修饰剂修饰的氧化铝负载铂纳米簇合物(Pt-PVP-γ-Al2O3)催化丙酮酸甲酯不对称氢化反应,采用甲醇的碱溶液做溶剂,着重考察了低温条件下催化剂的活性和对映选择性的变化.优化的反应条件为0℃,5.0MPaH2,[cinchonidine]=3.24×10-3mol/L,[KOH]=0.02mol/L,1h内丙酮酸甲酯不对称加氢的转化率为32.2%,对映选择性达到52.2%;The enantioselective hydrogenation of methyl pyruvate in the presence of γ-Al_2O_3 Supported Platinum Nanoclusters and chiral modifier cinchonidine was investigated. The results show that cinchonidine as a chiral modifier not only induce the enantioselectivity but also greatly accelerate the reaction rate. The effects of concentration of KOH and cinchonidine in MeOH, temperature, hydrogen pressure, reaction time on the asymmetric hydrogenation of methyl pyruvate have been studied. Under the optimum conditions of 0 ℃, 5.0 MPa H_2 and 3.24×10^(-3) mol/L of cinchonidine concentration in KOH/MeOH(0.02 mol/L) solution for 1 h, the conversion of methyl pyruvate and the e.e. value of product are 32.2% and (52.5%), respectively.

关 键 词：铂纳米簇合物 丙酮酸甲酯 辛可尼定 对映选择性加氢 

分 类 号：O643.32[理学—物理化学]