慢性喘息型支气管炎患者肌酸激酶活性的临床意义  

Clinical significance of serum creatine kinase measurement in patients with chronic asthmatic bronchitis

作　　者：刘家昌[1] 张安成[1] 孙耕耘[1] 

机构地区：[1]安徽医科大学第一附属医院呼吸内科

出　　处：《安徽医科大学学报》2003年第2期130-133,共4页Acta Universitatis Medicinalis Anhui

摘　　要：目的　探讨血清肌酸激酶 (sCK)活性测定在慢性喘息型支气管炎 (慢喘支 )临床中的应用价值。方法　测定 77例慢喘支患者及 2 0例正常对照组sCK、谷草转氨酶(sGOT)、乳酸脱氢酶 (sLDH)及羟丁酸脱氢酶 (sHBDH )活性 ,同步测定慢喘支急性期患者的血气指标及 1 6例慢喘支急性期患者的血清心肌型肌酸激酶同功酶 (sCK MB)活性。结果　慢喘支急性期患者sCK活性与缓解期组及正常对照组比较 ,差异无显著性 (P >0 0 5) ;慢喘支急性期不同病情组间比较 ,sCK活性有随病情加重而降低的趋势。 8例sCK活性异常降低的患者中 5例合并严重的并发症 ,2例sCK活性异常增高者在入院时均合并肺性脑病。慢喘支急性期患者sGOT、sLDH及sHBDH活性高于缓解期组及正常对照组(P <0 0 1 ) ,但随病情加重上述 3种血清酶活性差异无显著性。慢喘支急性期患者PaO2 除与sCK无相关性外 ,与其余3种血清酶均有相关性 (P <0 0 5)。结论　慢喘支急性期患者sCK活性异常增高或降低可能与患者病情严重有关 ,而sCK平均活性不能反映其病情严重程度 ;呼吸肌萎缩及其功能障碍可能是慢喘支急性期患者sCK平均活性未增高的主要原因 ;慢喘支急性期患者sCK活性与sGOT、sLDH。Objective To evaluate the clinical applications of th e detection of serum creatine kinase(sCK) in patients with chronic asthmatic bro nchitis. Methods The values obtained from the measurement of sC K, glutamic oxalacetic transaminase enzyme(sGOT), lactate dehydrogenase(sLDH) an d hydroxybutyrate dehydrogenase (sHBDH) in 57 cases of chronic asthmatic bronchi tis in exacerbation and 20 cases in remission were compared with the normal valu e measured in 20 healthy adults at the same period. Results The values of sGOT, sLDH and sHBDH of patients with chronic asthmatic bronchitis in exacerbation were significantly higher than that of normal people and patients with chronic asthmatic bronchitis in remission, while the value of sCK did not increase significantly. The differences of the values of sCK , sGOT ,sLDH and sHBDH between patients of different severity wereno thigh significant(P >0 0 5 ) .Conclu sion The averageactivi tieso fsCK ,sGOT ,sLDH and sHBDHarenotuse fulmarkers formoni toring the degree of severity and prognosisin patients with chronicasth maticbronc hitisine xacerbat ion .The extreme lyde creased orin creaseda ctivity of sCK in the patients may be related toth edisease severity .

关 键 词：慢性喘息型支气管炎 肌酸激酶活性 血清 谷-草转氨酶 乳酸脱氢酶 羟丁酸脱氢酶 

分 类 号：R562.21[医药卫生—呼吸系统]