胆固醇结石病人肝组织固醇携带蛋白2 mRNA的表达  

Expression of liver sterol carrier protein 2 mRNA in patients with cholesterol gallstone

作　　者：张淑坤[1] 崔乃强[1] 李东华[1] 张艳萍[1] 汤新之[2] 

机构地区：[1]天津市南开医院急腹症研究所,300100 [2]天津市医科大学基础医学院生化教研室,300070

出　　处：《中华肝胆外科杂志》2003年第7期423-425,共3页Chinese Journal of Hepatobiliary Surgery

基　　金：天津市卫生局 ( 0 0KYZP8)资助

摘　　要：目的　研究胆固醇结石病人和非胆固醇结石病人肝组织SCP2 mRNA的表达情况。方法　应用逆转录 聚合酶链反应 (RT PCR)技术 ,研究了 36例胆固醇结石病人和 30例非胆固醇结石病人肝组织SCP2 mRNA的表达水平。结果　胆固醇结石组SCP2 mRNA表达水平较非胆固醇结石组升高 ,差异有显著性。结论　胆固醇结石病人肝组织SCP2 mRNA表达水平升高 ,SCP2 基因表达过度可能是胆固醇结石形成的重要原因。Objective To investigate the expression level of liver sterol carrier protein 2 (SCP 2) mRNA in cholesterol gallstone patients and non cholesterol gallstone patients. Methods The expression of liver SCP 2 mRNA was determined in 36 cholesterol gallstone patients and 30 non cholesterol gallstone patients by RT PCR. Results The expression of SCP 2 mRNA was significantly increased in cholesterol gallstone patients as compared with the non cholesterol gallstone patients. Conclusions SCP 2 gene is overexpressed in cholesterol gallstone patients, indicating that SCP 2 may be one important cause of cholesterol gallstone.

关 键 词：胆固醇结石 肝组织 固醇携带蛋白2 基因表达 发病机制 

分 类 号：R657.4[医药卫生—外科学]