葛根素对糖尿病大鼠肾脏非酶糖基化和氧化应激的抑制作用  

The effects of Pueraria on the inhibition of nonenzymatic glycation and oxidation in kidneys of streptozocin-induced diabetic rats

作　　者：郭妍[1] 周传伟[1] 许健[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,210029

出　　处：《江苏医药》2003年第9期669-671,共3页Jiangsu Medical Journal

基　　金：南京医科大学科技发展基金 (NY990 3 5 )

摘　　要：目的　研究葛根素对糖尿病大鼠氧化应激反应和非酶糖基化的抑制作用。方法　糖尿病大鼠用葛根素治疗后 ,评价葛根素对糖尿病大鼠的非酶糖基化终末期产物、氧化应激及肾脏结构的影响。结果　与对照组比较 ,糖尿病大鼠糖化血清蛋白 (GSP)、糖基化终末期产物—肽链 (AGE P)、肾小球AGEs含量及肾小球截面积明显上升 ,同时丙二醛 (MDA)显著升高 ,而葛根素治疗组可明显降低糖尿病大鼠GSP、AGE P、MDA含量 ,明显降低肾小球内AGE含量及肾小球截面积。Objective To investigate the inhibitory effects of Pueraria on nonenzymatic glycation and oxidative stress of diabetic rats.Method Pueraria was injected into the abdomen of streptozotocin-induced diabetic rats for 8 weeks. The effects of pueraria on nonenzymatic glycation,oxiditive stress and kidney structure were evaluated.Results In the diabetic rats,glycation serum protein(GSP),advanced glycation end product-peptide(AGE-P),MDA of blood serum,AGEs in renal cortex and area of section cut straight through glomerulus are significantly increased than in normal controls.After being treated with Pueraria,GSP,AGE-P,MDA in blood serum,AGEs in renal cortex and area of section cut straight through glomerulus were significantly decreased than in untreated DM group.Conclusion Pueraria may inhibit both of nonenzymatic glycation and oxidative stress in kidneys of diabetic rats.

关 键 词：葛根素 糖尿病 肾脏非酶糖基化 氧化应激 抑制作用 

分 类 号：R587.1[医药卫生—内分泌]