脉冲电磁场对卵巢切除大鼠骨质疏松的预防作用  

Prevention Effect of Pulsing Electromagnetic Field on Osteoporosis in Ovariectomized Rats

作　　者：韩利华[1] 王全平[1] 罗二平[2] 余雷[2] 黄鲁豫[1] 戴贤文[1] 李晓娟[1] 

机构地区：[1]第四军医大学西京医院全军骨科研究所,西安710032 [2]第四军医大学生物医学工程系

出　　处：《中国矫形外科杂志》2004年第1期54-56,共3页Orthopedic Journal of China

基　　金：国家自然科学基金资助项目 (50 0 770 2 3)

摘　　要：目的 :观察脉冲电磁场 (PEMFs)对去势后大鼠骨质疏松症的预防作用。方法 :40只雌性SD大鼠随机分为 5组 :去势组、对照组和 3个PEMFs治疗组。治疗组磁场强度分别为 2、 4和 8G ,每天治疗 6h ,共 12周。术后12周处死动物 ,测定血清骨钙素、骨密度、生物力学参数、骨形态计量学分析。结果 :PEMFs治疗可以提高骨密度、骨小梁面积百分比、骨小梁宽度、骨小梁数目和股骨生物力学性能。PEMFs还可以降低去势后升高的血清骨钙素。结论 :PEMFs治疗可以预防大鼠卵巢切除引起的骨质疏松。Objective:To investigate the influence of pulsing electromagnetic field on prevention of osteoporosis in ovariectomized rats.Methods:Forty female SD rats were divided randomly into 5 groups:ovariectomy (OVX),sham operation and 3 OVX plus PEMFs-treated groups.PEMFs stimulation was applied for 6h per day,at a magnetic intensity of 2G,4G and 8G.All of them were sacrificed at 12 weeks after operation.Observed the change of serum osteocalcin,bone mineral density and histomorphometric measurement and calculations of distal femur and biomechanics characteristics.Results:PEMFs stimulation augmented and restored bone mineral density,trabecular area,trabecular thickness,trabecular number and biomechanics characteristics.PEMFs exposure also attenuated the higher serum osteocalcin concentrations of OVX rats.Conclusion:PEMFs may be useful in the prevention of osteoporosis resulting from ovariectomy.

关 键 词：骨质疏松症 脉冲电磁场 大鼠 卵巢切除术 预防 

分 类 号：R58[医药卫生—内分泌]