刺五加叶皂甙对Ⅱ型糖尿病大鼠GLP-1和血糖分泌的影响  

Effects of Ass Glp-1 and Blood Glucose in Experimental NIDDM Rats

作　　者：李艳君[1] 欧叶涛[1] 李晓涛[1] 扈清云[1] 杨扬[1] 姜吉文[1] 

机构地区：[1]佳木斯大学基础医学院解剖教研室,黑龙江佳木斯154007

出　　处：《解剖科学进展》2003年第3期238-239,共2页Progress of Anatomical Sciences

摘　　要：目的　研究刺五加叶皂甙 (acanthopanaxsenticosussaponin ,Ass)对实验性Ⅱ型糖尿病 (非胰岛素依赖型糖尿病 ,non insulindependentdiabetesmellitus,NIDDM)大鼠胰高血糖素样肽 1(glucagon likepeptide 1,Glp 1)和血糖的作用。方法　选用雄性Wistar大鼠 5 0只 ,用链尿佐菌素 2 5mg/kg加高脂、高糖、高热量饲养制成Ⅱ型糖尿病大鼠模型。应用放射免疫分析测定给予Ass后其空腹及口服葡萄糖后血浆中Glp 1和血糖变化。 结果　与正常组大鼠比较 ,Ass可使Ⅱ型糖尿病大鼠空腹及口服葡萄糖后Glp 1分泌升高、血糖水平降低。Objective To study the effects of acanthopanax senticosus saponin (Ass) on the levels of glucagon like peptide 1 (Glp 1) and blood glucose in experimental non insulin dependent diabetes mellitus(NIDDM) rats. Methods 50 male wistar rats were injected with STZ (25 mg/kg) via tail vein and fed on diet of high fat, high glucose and high calorie, the levels of Glp 1 and blood glucose were determined by radioimmunoassay. Results ASS can increase Glp 1 secretion, decrease the blood glucose secretion in NIDDM rats, no action in normal rats. Conclusion

关 键 词：刺五加叶皂甙 Ⅱ型糖尿病 大鼠 GLP-1 血糖 胰岛B细胞 

分 类 号：R255.4[医药卫生—中医内科学] R285.5[医药卫生—中医学]