颅脑伤时生长抑素mRNA表达及电针对其影响  

Effects of electron-acupuncture on somatostatin mRNA expression in rat brain after head injury

作　　者：刘平[1] 张留宝[1] 苏志达[1] 骆云[1] 郭建[2] 

机构地区：[1]第二军医大学南京军医学院组织学与胚胎学教研室,南京210099 [2]南京林业大学动物学教研室

出　　处：《解剖学杂志》2003年第4期364-368,共5页Chinese Journal of Anatomy

基　　金：江苏省自然科学基金课题 (K9845)

摘　　要：目的:探讨电针对颅脑伤的作用机理。方法:采用原位杂交组织化学技术,观察了实验性颅脑伤大鼠脑内生长抑素(SS)变化,并观察了电针治疗颅脑伤时对SS mRNA表达的作用。结果:电针可增加下丘脑室周核SS mR—NA表达,而在海马则降低SSmRNA表达。结论:颅脑伤时,电针与SS可能在缓解疼痛方面起协同效应,并且电针可能对海马神经元起保护作用。Objective : To approach the mechanism of electron-acupunture in treatment of head injury. Methods : So-matostatin mRNA in situ hybridization was used to observe the changes in the rats brain after injury and the effect of electron-acupuncture on somatostatin mRNA expression. Results : Electron-acupuncture increased somatostatin mRNA expression in the hypothalamic paraventricular nucleus, but reduced it in the hippocampal neurons. Conclusion : Electron-acupuncture and somatostatin may help to ease pain and protect hippocampal neurons in brain damage.

关 键 词：颅脑伤 生长抑素 MRNA 表达 电针 

分 类 号：R245[医药卫生—针灸推拿学]