硕苞蔷薇果化学成分研究(Ⅱ)  

Studies on Constituents of Rosa bracteata Fruits(Ⅱ)

作　　者：徐治国[1] 黄松[1] 杜方麓[1] 彭彩云[1] 田育望[1] 

机构地区：[1]湖南中医学院,长沙410004

出　　处：《中药材》2003年第12期867-869,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:从硕苞蔷薇(Rosa bracteata Wendl.)中寻找控制吗啡成瘾小鼠戒断症状的有效成分。方法:系统提取分离及反复硅胶柱层析,化学反应和光谱测定。结果和讨论:从果实中共分离出5个化合物。鉴定了其中4个,分别为枸橼酸三甲酸、3-羧基-3-羟基戊二酸二甲酯、3-羟基-3-甲氧基羰基戊二酸、枸橼酸钙,均为首次从蔷薇属植物中分得。Objective: To find the active constituents of Rosa bracteata Wendl. to antagonize withdrawal syndrome in morphinede-pendent mice. Methods: The constituents were isolated and purified by silica gel chromatography repeatedly. Their structures were made clear by chemical reactions and on the evidence of spectroscopy. Results and Conclusions: Five compounds were isolated from the fruits and four of them were determined as trimethly citrate, dimethyl 3-carboxyl-3-hydroxypentanedioate, 3-hydroxy-3-methoxycarbon-yl-pentanedioic acid, calcium citrate, which were found from the Rose genus plant for the first time.

关 键 词：硕苞蔷薇 化学成分 吗啡成瘾 枸橼酸三甲酸 3-羧基-3-基戊二酸二甲酯 3-基-3-羰基戊二酸 枸橼酸钙 

分 类 号：R259.955[医药卫生—中西医结合] R284.2[医药卫生—中医内科学]