阿达帕林凝胶个体化治疗寻常痤疮的临床研究  

Clinical Efficacy and Safety of Adapalene0.1%Gel with Individualized Treatment Regimen for Acne Vulgaris

作　　者：薛筑云[1] 杜承权[2] 刘国红[1] 毕志刚[1] 严松华[1] 骆丹[1] 

机构地区：[1]南京医科大学附属第一医院皮肤科,210029 [2]江苏省东海县人民医院皮肤科

出　　处：《中华皮肤科杂志》2003年第4期198-200,共3页Chinese Journal of Dermatology

摘　　要：目的评价0.1%阿达帕林凝胶个体化治疗寻常痤疮的疗效和安全性.方法81例轻、中度寻常痤疮患者,根据个体情况每日外用0.1%阿达帕林凝胶1～3次,总疗程6～8周.随机选择其中30例每周复诊,拍摄照片观察比较,指导调整治疗剂量.结果81例和其中30例痤疮患者痊愈率(总皮损数减少≥90%)分别为44.4%和73.4%;治疗中,皮脂溢出减少发生率83.3%;不良反应发生率39.5%,未影响治疗.结论本药个体化治疗寻常痤疮疗效良好,合理地增加日用药剂量可提高痊愈率;本药刺激性较低,患者皮肤对此药耐受性较好;疗程中阿达帕林凝胶可明显减少皮脂溢出.Objective To evaluate the clinical efficacy and safety of adapalene0.1%gel with individ-ualized treatment regimen for acne vulgaris(ITRAV).Methods Eighty-one patients with acne vulgaris of mild to moderate severity were treated with adapalene0.1%gel topically1to3times daily for6to8weeks according to the severity of the disease.Clinical responses were recorded and photographed weekly in30pa-tients randomly selected from the81patients,and treatment regimens were adjusted accordingly.Results It was shown that cure rates were44.4%and73.4%,in81recruited cases and30selected cases,respectively.Seborrhea decreased remarkably(83.3%)in the treatment.Side effects took place in39.5%of patients with-out interruption of the treatment.Conclusions ITRAV with adapalene0.1%gel has been proved to have an excellent response.Reasonably increasing the daily dosage could improve the cure rates.The cutaneous tolera-bility of the drug was generally good.Seborrhea could be reduced considerably during the treatment

关 键 词：阿达帕林凝胶 个体化治疗 寻常痤疮 临床研究 安全性 耐受性 给药方案 

分 类 号：R758.733[医药卫生—皮肤病学与性病学] R969[医药卫生—临床医学]