C反应蛋白对初发的无并发症的心肌梗死病人的预后价值  

Prognostic Value of C-reactive Protein in Patients of Initial Myocardial Infarction without Complications

作　　者：孙燕[1] 童步高[2] 

机构地区：[1]浙江省平湖市中医院心内科 [2]复旦大学附属中山医院心内科,上海200032

出　　处：《中国临床医学》2003年第2期227-228,共2页Chinese Journal of Clinical Medicine

摘　　要：目的 :探讨C反应蛋白与初发的无并发症的心肌梗死病人其心脏事件发生的关系。方法 :检测 6 0例初发无并发症的AMI发病 6～ 12h内CRP值 ,随访 13± 4个月后 ,比较分析其再发心源性死亡、不稳定型心绞痛、心肌梗死及充血性心力衰竭与其无再发心脏事件者的CRP值 ,同时按CRP值高低 ,将全组病人分成 4组 ,比较CRP值与心脏事件发生率的关系。结果 :全部初发的无并发症的心肌梗死再发心脏事件的病人 ,入院时CRP值均高于无再发心脏事件病人 (P <0 .0 5 ) ;随着CRP值的增加 ,心脏事件的发生率也随着增加 (P <0 .0 5 )。结论 :C反应蛋白是慢性炎症的独立敏感指标 ,对于无并发症的心功能良好的低危急性心肌梗死病人入院时的CRP值 ,对其预后有较高的预测价值 。Objective: To demonstrate the relationship between levels of C-reactive protein(CRP) and the presence of cardiac events in patients of initial myocardial infarction without complications. Methods: CRP levels were measured within 6 or 12 hours after the onset of the disease among 60 paients. During the average follow-up period of 13±4 months, CRP levels were compared between the patients with cardiogenic death, unstable angina pectoris, reoccurred myocardial infarction and congestive heart failure and those without cardiac events. On the other hand, according to CRP levels, four groups were classified in order to show the relationship between CRP levels and the incidence of cardiac events. Results: Among patients of initial myocardial infarction without complications, CRP levels were higher in those with reoccurred cardiac events(P<0.05); patients with elevated CRP levels exhibited a higher incidence of cardiac events(P<0.05). Conclusion: C-Reactive Protein(CRP) is a useful marker of chronic inflammation in patients with ischemic heart diseases, serum CRP level has a high prognostic value in those of relative lower-risk acute myocardial infarction.It is an independent cardiovascular risk factor.

关 键 词：C反应蛋白 并发症 心肌梗死 预后 稳定型心绞痛 充血性心力衰竭 慢性炎症 

分 类 号：R542.22[医药卫生—心血管疾病]