颈动脉粥样硬化血管重构及其后效影响因素的研究  

Study on Remodeling of Carotid Atherosclerosis and its After Effects

作　　者：张梅[1] 张运[1] 张园园[1] 葛志明[1] 黎莉[1] 戴晓华[2] 高月花[3] 

机构地区：[1]山东大学齐鲁医院,济南市250012 [2]山东省立医院 [3]山西省人民医院

出　　处：《中国超声医学杂志》2003年第5期334-336,共3页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金项目 ( N o. 6 0 2 710 15)

摘　　要：目的 :应用高频超声技术评价颈动脉粥样硬化血管重构改变 ,探讨血管重构的影响因素。方法 :在1 0 7例颈动脉粥样硬化斑块形成患者 ,应用高频超声测量血管总面积 (TVA)、管腔面积 (LA)、斑块面积 (PA)、面积狭窄率 (S)、偏心指数 (EI)和重构指数 (RI) ,并检测空腹血糖 (BS)、血清总胆固醇 (TC)、甘油三酯(TG)、一氧化氮 (NO)和内皮素 (ET)。结果 :正性重构组 TVA、 LA均显著大于负性重构组 (P<0 .0 5) ,正性重构组 TVA与 PA呈高度相关 (r=0 .84) ,无重构组、负性重构组 TVA与 PA呈中度相关 (r分别为 0 .65,0 .67) ;斑块部位 TVA与 PA呈正相关 (r=0 .77) ,LA与 PA无相关性。软斑组 RI大于硬斑组和钙化斑组 (P<0 .0 5)。糖尿病组 RI小于无糖尿病组 (P<0 .0 0 1 )。向心性斑块组 TC和 ET高于偏心性斑块组 (P<0 .0 0 1 )。舒张压与 TVA呈负相关 (r=- 0 .2 4 )。 ET与 PA及 S呈正相关 (r分别为 0 .52 ,0 .40 )。高密度脂蛋白胆固醇(HDL)与 TVA呈弱正相关 (r=0 .34)。结论 :应用高频超声技术可评价颈动脉粥样硬化血管重构现象 ,糖尿病、年龄、血压、 TC、 TG、 HDL和Objective:The aim of the study was to assess the after effects of vascular remodeling in atherosclerotic plaques by ultrasound and the contribution of risk factors in vascular remodeling Methods:The total vessel area(TVA),lumen area(LA), plaque area(PA), stenosis percentage(S), eccentric index(EI) and remodeling index(RI)were calculated Blood suger(BS), total cholesterol(TC), triglyceride(TG), nitraoxide(NO) and endothilin(ET) were measured Results:TVA in positive remodeling group was larger than that of nagetive remodeling group There were significantly correlation between TVA and PA( r =0 84) in positive remodeling group,moderate correlations in no remodeling group( r =0 65) and nagetive remodeling group( r =0 67) There were significant correlation between TVA and S( r =0 77) RI in soft plaque group was higher than that of hard or calcified plaque group RI in dibetes millitus group was higher than that of non dibetes millitus group TC and ET in conccentric plaque group were higher than those of eccentric plaque group The correlation between TVA and PA in concentric plaque group were higher than those in eccentric plaque group There were weak nagetive correlation between diastolic blood pressure and TVA( r =-0 24) There were positive correlations between ET and PA( r =0 52), ET and S( r =0 40),HDL and TVA( r =0 34) Conclusions:High frequency ultrasound provides a reliable method for evaluating the carotid artery remodeling Diabetes millitus,blood pressure,age,TC,TG,HDL and ET all related to carotid artery remodeling

关 键 词：动脉粥样硬化 血管重构 后效 高频超声技术 颈动脉 

分 类 号：R543.4[医药卫生—心血管疾病]