清脂胶囊对热毒血瘀证大鼠内皮功能及血液流变学的影响  

Influence of Qingzhi Capsule on Endothelial Function and Hemorheology in Rats with Epidemic Heat and Blood Stasis Syndrome

作　　者：史青[1] 聂淑琴[1] 杨庆[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2004年第1期28-31,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的 :研究清脂胶囊对热毒血瘀证模型大鼠血管内皮功能和血液流变学的影响。方法 :除正常组外 ,以高脂饲料造模 ,同时灌胃给药 ,于第 10d给药 1h后腹腔注射脂多糖 (LPS) 5 0 μg 只 ,6h后再给药一次 ,给LPS 2 4h后眼眶取血 ,用放免法检测内皮素 (ET)、白介素 1(IL 1) ,酶法检测超氧化物歧化酶 (SOD)和一氧化氮 (NO) ,腹主动脉取抗凝血检测血液流变学指标。结果和讨论 :清脂胶囊可提高模型大鼠的血清SOD含量 ,提高NO的释放 ,降低血浆ET ,明显降低血小板聚集率及全血黏度 ,因此对热毒血瘀证大鼠可从多方面对抗内皮功能紊乱及降低血液高粘凝聚状态。Objects:To investigate the influence of Qingzhi Capsule on endothelial function and hemorheology in rats with epidemic heat and blood stasis syndrome.Methods:The model was established with male rats induced by peritoneal injecting LPS and high fat diet.The level variations of ET,IL-1,SOD,NO in blood and the index of hemorheology were measured.Results:Qingzhi Capsule could increase the level of SOD and NO,and reduce the level of ET,and improve hemorheological parameters.Conclusion:These results indicated Qingzhi Capsule could improve endothelial function and hemorheology in rats with epidemic heat and blood stasis syndrome.

关 键 词：清脂胶囊 热毒血瘀证 炎症 内皮 血液流变学 

分 类 号：R285.5[医药卫生—中药学]