血清基质金属蛋白酶-9及转化生长因子β_1与糖尿病肾病的关系  

Clinical Study of Matrix Metalloproteinase-9 and transforming growth factor-β_1 related with diabetic nephropathy

作　　者：丁致民[1] 吴建新[2] 李媛媛[2] 欧阳[2] 祝恕德[1] 吴梦青[1] 陆悦[1] 邓薇[1] 

机构地区：[1]北京积水潭医院内科,100035 [2]首都儿科研究所

出　　处：《中国糖尿病杂志》2003年第5期321-323,共3页Chinese Journal of Diabetes

摘　　要：目的　观察 2型糖尿病患者 (T2DM)血清基质金属蛋白酶 9(MMP 9)、转化生长因子β1(TGF β1)、IV型胶原 (CIV)的变化 ,探讨其在糖尿病肾病 (DN)进展中的作用。　方法　根据尿白蛋白排泄率 (UAER)将 6 4例T2DM患者分为正常白蛋白尿 (NA)组、微量蛋白尿 (MA)组、临床白蛋白尿 (ODN)组 ,分别检测各组的MMP 9、TGF β1、CIV。　结果　血清MMP 9含量在MA组及ODN组较正常对照 (NC)组明显升高 (P <0 .0 1) ,且ODN组较MA组明显升高 (P <0 .0 1)。血清TGF β1含量NA组、MA组及ODN组均较NC组明显升高 (P <0 .0 1) ,MA组及ODN组较NA组升高明显 (P<0 .0 1)。血清CIV含量ODN组明显高于其他三组 (P <0 .0 1) ,NA组、MA组虽较NC组升高但无显著差异 (P >0 .0 5 )。　结论　血清MMP 9、TGF β1升高在DN的发生。Objective To study whether serum matrix metalloproteinase 9, serum transforming growth factor β 1, serum type C IV collagen concentrations are alternatoin in various stages of patients with T2DM. Methods 64 cases T2DM patients were divided into three groups according to urine albumin excretion rate (UAER):normoalbuminuria (NA)group and microalbuminuria (MA) group and overt diabetic nephropathy (ODN)group. Serum MMP 9,TGF β 1 and C IV were detected in all cases. Results Serum MMP 9 in MA and ODN groups were higher than NA and normal control groups ( P <0.01);Serum TGF β 1 in NA,MA and ODN groups were higher than NC group( P <0.01); Serum C IV in ODN group was higher than other three groups( P <0.01)。 Conclusion Higher Serum MMP 9、TGF β 1 plays an important role in the development of diabetic nephropathy in T2DM.

关 键 词：血清 基质金属蛋白酶-9 转化生长因子β1 糖尿病肾病 IV型胶原 尿白蛋白 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]