经动脉导管四氧化三铁微粒栓塞临床应用价值  

The Clinical Applied Value of Embolic Substance of Microspheres of Fe_3O_4

作　　者：程新宝[1] 袁曙光[2] 

机构地区：[1]郑州市第五人民医院放射科,河南郑州450003 [2]昆明医学院附属第二医院放射科

出　　处：《实用放射学杂志》2003年第7期631-634,共4页Journal of Practical Radiology

摘　　要：目的　探讨四氧化三铁 (Fe3 O4)微粒栓塞肿瘤及血管性疾病临床应用价值。方法　临床 10 6例患者 ,采用Seldinger技术插管 ,置导管端于靶血管内 ,在X线电视监测下 ,用Fe3 O4微粒或Fe3 O4化疗药物混悬液栓塞。结果　恶性肿瘤 94例 ,良性血管性病变 12例 ,多数患者栓后 1月CT、USG或DSA复查 ,肿瘤明显缩小。 18例肿瘤栓塞后手术切除 ,病理检查 :肿瘤组织坏死 10 0 %。血生化检查 :肝肾功能有轻度变化 ,经一般临床处理可接近栓塞前正常水平或优于术前水平。原发性肝癌栓塞后血清AFP多数有明显下降 ,血清铁浓度栓塞前后变化显示 :Fe3 O4微粒栓塞治疗有助于血清铁浓度指标正常值的维持。栓塞前后DSA对照显示 ,1月后Fe3 O4微粒由栓塞动脉血管近端移向远端末梢 ,临床观察栓后综合征明显下降。结论　通过 10 6例患者临床栓塞治疗 ,Fe3 O4微粒是一种理想的永久性颗粒栓塞剂。Objective To investigate the clinical applied value of magnetic mitomycin microspheres and magnetic Fe 3O 4 in treating tumors and vascular diseases by embolism.Methods The embolic therapy in 106 cases useing microspheres or drugs of Fe 3O 4 under TV-guided through catheterization using Seldinger's technique were performed.Results In 94 malignant tumors and 12 benign vascular diseases.The most of tumors became small remarkably on CT,USG or BSA one month later after embolism.Pathology showed that necrosis of cancer tissue was 100 percent.Examination of blood biochemistry showed that the functions of liver and kidney had some changes,however these functions could recover to normal or better after therapy.AFP decreased significantly after embolism in most primary hepatic cancer.Changes in density of serum Fe before and after embolism showed that embolism of Fe 3O 4 microspheres could maintain serum Fe in normal condition.DSA showed that microspheres of Fe 3O 4 were moved from the near portion to the peripheral embolic arteries after embolism one month later and the clinical symptoes improved.Conclusion Fe 3O 4 is good embolic substance and can avoid some complications by embolism.

关 键 词：经动脉导管栓塞 四氧化三铁 临床应用 颗粒栓塞剂 X线监测 SELDINGER技术 

分 类 号：R815[医药卫生—放射医学]