中草药液体型药贴研制及其治疗慢性肾衰竭临床研究  

Preparation of the Chinese herbal drugs liquid paste and its clinical study in treatment of chronic renal failure

作　　者：吴锡信[1] 刘志龙[2] 张曦[3] 曾志为 周轶[3] 蔡越秀[3] 彭健[1] 李书香[5] 赵东波[3] 

机构地区：[1]中山大学附属第五医院肾内科,广东珠海519000 [2]广州中医药大学附属珠海医院,广东珠海519000 [3]暨南大学医学院第三附属医院,广东珠海519000 [4]珠海市拱北医院,广东珠海519000 [5]珠海出入境检验检疫局检验检疫技术中心,广东珠海519000

出　　处：《中国中西医结合急救杂志》2004年第1期39-41,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：广东省中医药局科研基金资助(101141);广东省科技计划项目基金资助(2002A3010303);珠海市科技计划项目基金资助(PC200310062);珠海市医学科研基金资助(2002A3010303;配套)

摘　　要：目的 :自行研制中草药液体型药贴 (CHDL P) ,观察其治疗慢性肾衰竭 (CRF)的临床疗效及副作用。方法 :将 2 7例非透析 CRF志愿患者随机分两组。对照组给予低蛋白饮食 (L PD)和支持对症治疗 ;药贴组在L PD、支持对症治疗基础上加用 CHDL P(由仙灵脾、枸杞子、紫河车、红参、律草、生大黄、甘草等中草药经特殊工艺加工制成 )分别贴敷每侧肾区及脐下 6 cm与前正中线交界处 ,每 2 d用 1套药贴。两组疗程均为 1个月。观察用药前后两组患者的各种临床症状改善率 ,并测定尿素氮、血清肌酐、肾小球滤过率、血钙、血磷等指标 ,根据Mitch法观察两组治疗前后肾功能变化。结果 :CHDL P能显著缓解非透析 CRF患者的消化道症状、神经精神症状、呼吸道症状与皮肤瘙痒 ,改善 CRF的高血压与贫血 ,增加 CRF患者的尿量 ,显著降低尿素氮、血清肌酐、血磷水平 ,提高肾小球滤过率与血钙水平 ,并能显著延缓非透析 CRF的病程进展。 CHDL P使用过程中无不良反应。结论 :用 CHDL P治疗 CRF是一种可行且有效的外治法 ,适合于胃肠道症状较为突出且经济条件不允许作维持性透析或肾移植的 CRF患者。Objective: To prepare Chinese herbal drugs liquid paste (CHDLP) by ourself and observe its clinical effect and sideeffect for treating chronic renal failure(CRF). Methods: CHDLP was prepared by modern pharmacy technique with herb of shorthorned epimedium(仙灵脾), fruit of barbary wolfberry(枸杞子), dried human placenta(紫河车), root of the red ginseng(红参), Li grass(律草), crude rhubarb(生大黄), liquorice(甘草) and so on. Twenty-seven cases with CRF were divided into the control group(14 cases) and the CHDLP group(13 cases) randomly. Patients in the control group were treated with low protein diet(LPD) and to treat symptom. Patients in the CHDLP group were treated with CHDLP, which were respectively sticked on the renal areas and the juncture between 6 cm below the umbilicus and the front midmost line, use 1 unit per two days, on the base of treatment of LPD and treatment to symptom. The treatment courses of two groups were all 1 month. The improving rate of the clinical symptoms were observed, the blood urea nitrogen(BUN), serum creatinine(SCr), glomerular filtration rate(GFR), calcium and phosphor were measured before and after treatment. The renal function change before and after treatment was observed according to Mitch's method. Results: CHDLP could significantly lighten the alimentary canal symptom, the spirit and nerve symptom, the respiratory canal symptom and the skin titillation, and improve the high blood pressure and anemia, increase urine quantity, and significantly reduce BUN, SCr and phosphor, significantly increase GFR and calcium in patients with CRF. It could significantly postpone the progression of chronic renal failure. There was no side-effect in the course of using CHDLP. Conclusion: CHDLP is a feasible and effective method in treatment of CRF, and adapting to the patients with the serious alimentary canal symptom but could not perform the dialysis or the renal transplant due to poverty.

关 键 词：中草药液体型药贴 慢性肾衰竭 临床研究 副作用 中西医结合 胃肠道症状 

分 类 号：R277.5[医药卫生—中医学]