黄芪对急性脑创伤后局部脑皮质血流速度变化的影响  

Experimental study of astragulus(黄芪) on regional cerebral blood flow velocity post injury in rats with acute cerebral injury

作　　者：穆士卿[1] 肖安平[1] 李拴德 汪海波[1] 李凯[1] 吴云志[1] 

机构地区：[1]南京医科大学第二附属医院神经外科,江苏南京210000 [2]兰州军区神经外科研究所,陕西宝鸡721004

出　　处：《中国中西医结合急救杂志》2004年第1期45-46,共2页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：兰州军区医药卫生科研计划项目 ( L XH990 8)

摘　　要：目的 :观察脑创伤后黄芪对局部脑皮质血流速度 (r CBFV)变化的影响 ,为黄芪在脑创伤中的应用提供理论依据。方法 :以大鼠为实验动物 ,随机分成正常对照组、盐水对照组和黄芪组 ;采用改进的 Feeney's方法建立颅脑创伤模型 ,正常对照组 5只动物 ,盐水对照组和黄芪组各 35只 ,均分为创伤后 1、3、6、8、12、2 4和4 8h等 7个时间点 ,测定创伤脑组织 r CBFV。结果 :急性脑创伤早期 ,r CBFV即呈下降趋势 ,其中伤后 1h时r CBFV有所下降 ,伤后 2 4 h时 r CBFV下降至最低点 ,伤后 4 8h血流速度开始回升。黄芪组各时间点 r CBFV下降幅度明显减少 ,与盐水对照组比较具有统计学意义 (P<0 .0 5 )。结论 :黄芪具有明显增加 r CBFV的作用 ,其机制与黄芪的神经血管保护作用有密切关系。Objective: To study the influences of astragulus(黄芪) on regional cerebral blood flow velocity(rCBFV) in rats with acute cerebral injury. Methods: The rats were randomly divided into three groups: normal control group(n=5), normal saline control group(n=35) and astragulus group(n=35). Local traumatic brain injury model was extablished by the improved Feeney's method. The rCBFV was measured at 1, 3, 6, 8, 12, 24 and 48 hours in normal saline control and astragulus group after brain injury in the rats, and compared to that of the normal control. The influences of astragulus on rCBFV were observed. Results: The rCBFVwere decreased obviously in early stage after acute traumatic brain injury and reached the lowest level at 24 hours, gradually recoved at 45 hours. Astragulus significantly inhibited the decrease of rCBFV and the difference was significant compared to the normal saline control group (P<0.05). Conclusion: Astragulus can increase the rCBFV in rats, the mechanism is related to the neuro-vascular protection of astrogulus.

关 键 词：黄芪 急性脑创伤 脑皮质 血流速度 神经保护 微血栓形成 

分 类 号：R285[医药卫生—中药学]