甲基苯丙胺神经毒性机制的研究进展  

The progress in the mechanisms of methamphetamine neurotoxicity

作　　者：周军兰[1] 梁建辉[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083

出　　处：《中国药理学通报》2003年第5期485-488,共4页Chinese Pharmacological Bulletin

摘　　要：目前 ,国际上甲基苯丙胺的滥用呈上升趋势 ,对甲基苯丙胺神经毒性的研究重新受到重视。长期滥用甲基苯丙胺可以引起中枢神经系统神经化学、神经病理和行为的改变。过量多巴胺的氧化作用、谷氨酸介导的兴奋性毒性作用、线粒体功能紊乱以及药物慢性作用所致的神经元凋亡是造成中枢神经系统损伤的主要机制。此外 ,对Caspases级联反应诱导的凋亡及其有关的凋亡调控基因在甲基苯丙胺神经毒性中的作用也进行了讨论。Research into methamphetamine-induced neurotoxicity has experienced a resurgence in recent years. This is due to an increased abuse of the substance internationally. The long-term abuse of methamphetamine will result in neurochemical, neuropathological and behavioral changes. Recent data implicate that dopamine oxidation, glutamate-induced excitotoxicity, disruption of mitochondria, and apoptosis are involved in the injury of methamphetamine to central nervous system. Further, Involvement of cell death-related genes in the neurotoxic effects of methamphetamine is also discussed.

关 键 词：甲基苯丙胺 神经毒性 活性物 细胞凋亡 

分 类 号：R971[医药卫生—药品] R977.9[医药卫生—药学]