连苏止呕胶囊对化疗呕吐家鸽胃肠激素和神经递质的影响  

Study of pigeons gastrointestinal hormones and neurotransmitters affected by vomiting due to chemotherapy

作　　者：张再康[1] 白建乐[1] 韩晓[1] 冯瑞雪[1] 李士懋[1] 孙建宁[2] 张明泉[1] 曹刚[1] 李国明[1] 

机构地区：[1]河北医科大学中医学院,石家庄050091 [2]北京中医药大学中药学院药理学教研室,北京100102

出　　处：《中国药理学通报》2003年第5期585-587,共3页Chinese Pharmacological Bulletin

基　　金：河北省教育厅资助课题 ;No 2 0 0 2 2 2 8

摘　　要：目的　探讨连苏止呕胶囊抗化疗呕吐的内在机制。方法　采用家鸽腹腔注射顺铂法制造模型 ,用放免试剂盒检测胃肠激素 ;用高效液相色谱 电化学检测法检测神经递质。结果　连苏止呕胶囊高剂量组能升高外周血中表皮生长因子 (EGF)的含量 (P <0 0 5 ) ,连苏止呕胶囊低剂量、高剂量组能降低外周血中胃泌素 (Gas)的含量 (P <0 0 5 ,P <0 0 1)。脑干中连苏止呕胶囊高、低剂量组 5 羟色胺 (5 HT)、多巴胺 (DA)的含量变化均与模型组差异有统计学意义 (P <0 0 5 ,P <0 0 1)。结论　连苏止呕胶囊对胃肠黏膜起到了一定的保护作用 ,对胃肠运动具有改善作用。它可能既是 5 HT受体拮抗剂 ,又是DA受体拮抗剂 ,而且作用较强。AIM To study the mechanism of anti-vomiting due to chemotherapy by TCM. METHODS We make animal model by injecting the chemical medicine cisplatin in pigeon's abdomen,measuring the quantities of gastrointestinal hormones by radioimmunoassay and neurotransmitters by HPLC-ED. RESULTS The high dose group of antiemetic capsule of Liansu can obviousluy raise the level of epidermal growth factor(EGF) in the blood ( P< 0.05). The low dose group can increase the level of gastrin(Gas) in the blood ( P<0.05,P< 0.01).In brainstem there is a great difference between the antiemetic capsule of Liansu and the model group ( P< 0.05, P< 0.01). CONCLUSIONS The antiemetic capsule of Liansu can protect the gastrointestinal mucosa and improve the gastrointestinal motility. The antiemetic capsule of Liansu is not only 5-hydroxytryptamine(5-HT) receptor antagonist,but dopamine (DA) receptor antagonist,and the effect is stronger.

关 键 词：连苏止呕胶囊 家鸽 化疗呕吐 胃肠激素(EGF Gas) 神经递质(5-HT DA) 

分 类 号：R287[医药卫生—中药学] R944.5[医药卫生—中医学]