单纯性肥胖症儿童运动训练前后血管内皮分泌功能及氧化低密度脂蛋白的变化  

Changes of the function of vascular endothelial secretion and OX-LDL in obese children before and after exercise intervention

作　　者：周曙明[1] 丘惠娴[1] 邱小丽[1] 

机构地区：[1]深圳市龙岗中心医院儿科,深圳518116

出　　处：《中华物理医学与康复杂志》2003年第5期273-274,共2页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的　观察单纯性肥胖症儿童运动训练前、后血管内皮分泌功能 ,氧化低密度脂蛋白 ,体重改变的特点。方法　收集 8～ 14岁单纯性肥胖症儿童 3 0例 (肥胖组 ) ,正常儿童 3 0例 (对照组 )。肥胖组进行为期 8周、每周 5d、每天 1h的运动训练 ,测定其运动训练前、后的内皮素 (ET)、6 酮前列环素 (6 K PGF1α)、一氧化氮 (NO)、氧化低密度脂蛋白 (OX LDL)及体重 ;测定对照组儿童的内皮素 (ET)、6-酮前列环素 (6 K PGF1α)、一氧化氮 (NO)、氧化低密度脂蛋白 (OX LDL)。结果　肥胖组儿童的ET、OX LDL明显升高 ,NO、6 K PGF1α明显降低 ,与对照组比较 ,差异有显著性 (P <0 .0 1)。运动训练后肥胖组儿童的ET、OX LDL明显下降 ,而 6 K PGF1α、NO明显升高 ,与治疗前比较 ,差异有显著性 (P <0 .0 1)。结论　单纯性肥胖症儿童血管内皮分泌功能及OX LDL发生紊乱 ,而运动训练能使其功能得到改善。Objective To observe the changes of the function of vascular endothelial secretion, levels of OX-LDL and body-weight of obese children after exercise intervention. Methods Thirty children with obesity at the age of 8 to 14 years and 30 normal children were enrolled in this experiment. The obese children (exercise group) received a session of 1 hour's exercise each day, 5 days a week for 8 weeks. The levels of ET, 6-K-PGF1α,NO, OX-LDL and body-weight were then measured and compared with that of their pre-exercise state and that of the normal children (control group). Results The levels of ET and OX-LDL were increased, while the levels of NO and 6-K-PGF1α were decreased in the obese children in comparison with the normal controls, the difference was statistically significant ( P <0.01). After exercises, the levels of ET and OX-LDL decreased, while 6-K-PGF1α and NO increased significantly as compared with those before exercise in the obese children( P <0.01). Conclusion The function of vascular endothelial secretion and levels of OX-LDL were disordered in children with obesity. Exercise can definitely improve the metabolic functions of children with obesity.

关 键 词：单纯性肥胖症 儿童 运动训练 血管内皮分泌功能 氧化低密度脂蛋白 

分 类 号：R723[医药卫生—儿科]