食管癌低氧放疗的临床研究  

A STUDY ON HYPOXYRADIOTHERAPY FOR ADVANCED ESOPHAGEAL CANCER

作　　者：梁军[1] 孙朝阳[2] 张文正 

机构地区：[1]第四军医大学唐都医院放疗科,710038 [2]第四军医大学西京医院放疗科,西安710032 [3]运城市中心医院放疗科,山西044000

出　　处：《中国现代医学杂志》2003年第10期11-13,共3页China Journal of Modern Medicine

摘　　要：目的 :探讨食管癌低氧放疗的临床应用价值。方法 :1992年 2月～ 1993年 6月 ,112例食管癌随机分为低氧放疗组和常规放疗组各 5 6例。两组均采用腔内照射与外照射相结合的方法。腔内照射 :6Gy/次 ,1次 /周 ,总剂量DT18Gy。体外照射 :1.8～ 2 .0Gy/次 ,5次 /周 ,照射剂量DT60Gy。低氧组佩戴低氧呼吸装置 (相当于呼吸含氧量为 10 .5 %的低氧气体 )。结果 :低氧组和常规放疗组的肿瘤消退情况Ⅰ ,Ⅱ ,Ⅲ和Ⅳ级分别为2 9.5 %和 3 2 .2 % ,46.0 %和 42 .5 % ,14.1%和 15 .3 % ,10 .4和 10 .0 % (P >0 .0 5 ) ,两组比较差异无显著意义 ;低氧组和常规组的 1,3 ,5年生存率分别为 65 .5 %和 2 6.6% ,2 5 .4%和 10 .7% ,2 1.8%和 8.1% ,两组比较差异有显著意义 (P <0 .0 5 )。低氧组放疗副作用和并发症的发生率较常规放疗组低。结论 :低氧放疗可能会提高食管癌病人的生存率 ;Objective: To evaluate the hypoxyradiotherapy in the treatment of esophageal cancer.Methods: From Feb. 1992 to Jun. 1993,112 patients with esophageal cancer were randomized into two groups, hypoxyradiotherapy group (study group with 56 patients) and conventional radiotherapy group (control group 56 patients). All patients were given with external-beam pelvic irradiation combined with intracavitary application. The dose ofintracavity irradiation was 18Gy/3 weeks,that of external-beam irradiation dose 60Gy /6～8weeks. The patients in study group inhale the gas which contains 10.5% oxygen inconcentration.Results:The results show that immediate response showed no any obviousdifference in both groups. The long-term survival rates and immediate side effects were better in study group. Conclusion: Our clinical trial indicate that the hypoxyradiotherapy of esophageal cancer could decrease the rate of acute side-effects, treatment complications, and increase the long-term survival rates.

关 键 词：食管癌低氧放射放射治疗 

分 类 号：R811[医药卫生—放射医学]